Results 11 to 20 of about 209,035 (336)

Development of a Risk Score for QT Prolongation in the Intensive Care Unit Using Time-Series Electrocardiogram Data and Electronic Medical Records [PDF]

Healthcare Informatics Research, 2021
Objectives Drug-induced QT prolongation can lead to life-threatening arrhythmia. In the intensive care unit (ICU), various drugs are administered concurrently, which can increase the risk of QT prolongation.
Tae Young Kim, Byung Jin Choi, Yeryung Koo, Sukhoon Lee, Dukyong Yoon   +4 more
doaj   +1 more source

Prolonging effect of polyvinyl alcohol on the drug release

Chimica Techno Acta, 2022
Polymers are currently of interest as drug delivery systems. The use of polymeric forms of medicinal substances will eliminate or reduce the disadvantages of traditional drugs.
Anzhela Shurshina, Roman Lazdin, Elena Zakharova, Anastasiya Titlova, Elena Kulish   +4 more
doaj   +1 more source

Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19).

JAMA cardiology, 2020
Importance Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias.
Nicholas J. Mercuro, C. Yen, David Shim, T. Maher, Christopher M. McCoy, P. Zimetbaum, H. Gold   +6 more
semanticscholar   +1 more source

QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin

Heart Rhythm, 2020
Background There is no known effective therapy for patients with COVID-19. Initial reports suggesting the potential benefit of Hydroxychloroquine/Azithromycin (HY/AZ) have resulted in massive adoption of this combination worldwide ...
E. Chorin, Lalit Wadhwani, S. Magnani, Matthew Dai, E. Shulman, C. Nadeau-Routhier, R. Knotts, Roi Bar-Cohen, Edward V. Kogan, Chirag R. Barbhaiya, A. Aizer, Douglas S. Holmes, S. Bernstein, Michael A. Spinelli, David S. Park, Carugo Stefano, L. Chinitz, Lior Jankelson   +17 more
semanticscholar   +1 more source

Managing drug-induced QT prolongation in clinical practice

Postgraduate medical journal, 2020
Many drug therapies are associated with prolongation of the QT interval. This may increase the risk of Torsades de Pointes (TdP), a potentially life-threatening cardiac arrhythmia.
R. Khatib, Fatima Sabir, Caroline Omari, C. Pepper, M. Tayebjee   +4 more
semanticscholar   +1 more source

Gerekçeleri ve Kıymeti Açısından Arap Belâgatinde Îcâzlı Anlatım

Eskiyeni, 2023
Kelâmın muktezâ-i hâle uygun olması ve zikredilen lafızlar ile mananın birbirine denk olması sözün beliğ olmasının bir gereğidir. Söz bazen muhatabın anlamasını kolaylaştırmak bazen de sözü zihne iyice yerleştirmek gibi sebeplerle uzatılabilmekte ve ...
Yaşar Fatih Akbaş
doaj   +1 more source

Chloroquine-induced QTc prolongation in COVID-19 patients

Netherlands Heart Journal, 2020
Background In the battle against the SARS-CoV‑2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients.
M. P. H. van den Broek, J. Möhlmann, B. Abeln, M. Liebregts, V. van Dijk, E. M. W. van de Garde   +5 more
semanticscholar   +1 more source

Liftings of metallic structures to tangent bundles of order r

AIMS Mathematics, 2022
It is well known that the prolongation of an almost complex structure from a manifold $ M $ to the tangent bundle of order $ r $ on $ M $ is also an almost complex structure if it is integrable.
Mohammad Nazrul Islam Khan, Uday Chand De   +1 more
doaj   +1 more source

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

Clinical pharmacology and therapy, 2020
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide.
H. Vargas, M. Rolf, Todd A. Wisialowski, W. Achanzar, A. Bahinski, A. Bass, Charles T Benson, K. Chaudhary, N. Couvreur, C. Dota, M. Engwall, C. Michael Foley, D. Gallacher, A. Greiter-Wilke, J. Guillon, B. Guth, H. Himmel, C. Hegele‐Hartung, Maki Ito, S. Jenkinson, K. Chiba, A. Lagrutta, P. Levesque, E. Martel, Y. Okai, Ravikumar Peri, A. Pointon, Yusheng Qu, A. Teisman, M. Traebert, T. Yoshinaga, G. Gintant, D. Leishman, J. Valentin   +33 more
semanticscholar   +1 more source

Risk of QTc prolongation among cancer patients treated with tyrosine kinase inhibitors

International Journal of Cancer, 2020
QTc interval prolongation can lead to life‐threatening complications such as Torsade de Pointes (TdP), ventricular tachycardia (VT) and sudden cardiac death (SCD). It can occur with tyrosine kinase inhibitors (TKIs) but comparative real‐world analyses on
Anan A. Abu Rmilah, G. Lin, K. Begna, P. Friedman, J. Herrmann   +4 more
semanticscholar   +1 more source