Results 31 to 40 of about 133,148 (292)

Torsade de Pointes/QT Prolongation Associated with Antifungal Triazoles: A Pharmacovigilance Study Based on the U.S. FDA Adverse Event Reporting System（FAERS）

Journal of Pharmacy & Pharmaceutical Sciences, 2022
Purpose: Torsade de pointes (TdP)/QT prolongation is a fatal adverse event (AE) when using antifungal triazoles. We aimed to compare the AE signals of TdP/QT prolongation and onset time among different drugs of this kind comprehensively.
Zicheng Yu, Xiaolan Liao
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Major-Minor Tonality, Schenkerian Prolongation, and Emotion: A commentary on Huron and Davis (2012)

Empirical Musicology Review, 2013
On average, melodies in minor keys have smaller intervals between successive tones than melodies in major keys—consistent with the emotional difference between major and minor (Huron, 2008).
Richard Parncutt
doaj   +1 more source

Association between PR interval prolongation and electro-anatomical substrate in patients with atrial fibrillation. [PDF]

PLoS ONE, 2018
BACKGROUND:Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical routine. Left atrial (LA) electro-anatomical remodelling in AF patients indicates disease progression and is associated with poor therapeutic success.
Katja Schumacher, Petra Büttner, Nikolaos Dagres, Philipp Sommer, Borislav Dinov, Gerhard Hindricks, Andreas Bollmann, Jelena Kornej   +7 more
doaj   +1 more source

QRS fragmentation versus QRS prolongation in predicting right ventricular enlargement and dysfunction in children and adults with repaired Tetralogy of Fallot

International Journal of Cardiology Congenital Heart Disease, 2023
Patients with repaired Tetralogy of Fallot (rTOF) have risks of late life-threatening sequelae, including right ventricular (RV) dilation and failure, arrhythmias, and sudden death. QRS prolongation is a well-known ECG predictor of these outcomes but has
Stephanie Gaydos, Anthony Hlavacek, Susan Evenhouse, Jacob Strelow, Shahryar Chowdhury, Lanier Jackson   +5 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Prolongations [PDF]

Essais, 2022
Bienvenu-Crélot, Manon, Kiefel, Layla, Lageyre, Julie, Marques-Verhille, Noémie, Mazzero, Hugo, Oulkebous, Leila, Prévost, Caroline, Sasportes, Aurore, Turck, Blanche   +8 more
openaire   +2 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Coronavirus disease 2019 (COVID-19) and QTc prolongation

BMC Cardiovascular Disorders, 2021
Introduction The cause-and-effect relationship of QTc prolongation in Coronavirus disease 2019 (COVID-19) patients has not been studied well. Objective We attempt to better understand the relationship of QTc prolongation in COVID-19 patients in this ...
Khalid Changal, David Paternite, Sean Mack, Spiro Veria, Rehana Bashir, Mitra Patel, Ronak Soni, Muhammad Ali, Tanveer Mir, Mujeeb Sheikh, P. Kasi Ramanathan   +10 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source