Results 121 to 130 of about 1,125,084 (303)

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

open access: yesAdvanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi   +14 more
wiley   +1 more source

A review of the international literature on the role of outside facilitators in the delivery of school-based sex education

open access: yes, 2009
Schools are one of the main sites where knowledge can be imparted on sexuality and relationships. There is widespread parental support in the Irish context for the provision of school-based sex education (Morgan, 2000; North Western Health Board, 2004;
Doyle, Louise   +6 more
core  

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

open access: yesAdvanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang   +8 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Irish contraception and crisis pregnancy [ICCP] study: A survey of the general population

open access: yes, 2004
Crisis pregnancy is a complex challenge for individuals and societies alike. Its prevention and management needs to be informed by up-to-date and locally applicable information on knowledge, attitudes and behaviours concerning sexual practices and ...
McGee, Hannah   +3 more
core  

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

open access: yesAdvanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan   +17 more
wiley   +1 more source

Pregnancy at work: a national survey

open access: yes, 2011
The aim of this study is to fill the gap in knowledge around women’s experiences in paid work in Ireland during pregnancy and after childbirth using data from the first nationally representative survey of mothers.
Russell, Helen   +2 more
core  

Challenges of a Pregnancy Gone Wrong: Pregnancy Complications, Illness Perceptions and Distress [PDF]

open access: yes, 2014
Women with pregnancy complications need to cope with a pregnancy that can have life changing consequences. The objective of this research project was to understand the experience of women who had been diagnosed with a pregnancy complication. The research
Currie, Jane Christina Helen
core  

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

open access: yesAdvanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo   +14 more
wiley   +1 more source

Pregnancy discrimination in the workplace: legal framework and review of legal decisions 1999 to 2008

open access: yes, 2011
The experience of being in employment while pregnant or returning to work after having a child is not well researched in Ireland or indeed internationally.
Russell, Helen, Banks, Joanne
core  

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