Results 271 to 280 of about 111,832 (326)

Exonic Variation and Its Clinical Impact in 7221 Old Order Amish

American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.
ABSTRACT The Amish of Lancaster County, PA has been the focus of genetic studies for many years due to its demographic history and unique genetic makeup that includes a historical bottleneck event and subsequent genetic drift, resulting in a marked decrease in genetic diversity and increased frequency of some variants that have substantially shaped the
Braxton D. Mitchell, Ebuka Onyenobi, Joshua P. Lewis, Brady Gaynor, James A. Perry, Kristin Maloney, Jeffrey R. O'Connell, Jessica Tiner, Amber L. Beitelshees, Cristopher V. Van Hout, Patrick F. McArdle, Huichun Xu, Erik G. Puffenberger, Karlla W. Brigatti, Melanie Daue, Hilary B. Whitlatch, Anna Alkelai, Alejandro A. Schäffer, John Overton, Elizabeth A. Streeten, Toni I. Pollin, Alan R. Shuldiner   +21 more
wiley   +1 more source

Twenty-Four Hour Rhythms in Cardiovascular Physiology. [PDF]

Acta Physiol (Oxf)
Thomsen MB.
europepmc   +1 more source

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia‐inducible factor‐2α inhibitor, in healthy participants

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3366-3377, December 2025.
Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi, Ji Yun Kim, Lisa Seitz, Lixia Jin, Paul G. Foster, Kai H. Liao, Tzuling Cheng, Elaine Paterson, Maria Velinova, Nicole Rivera Rosario, Reza Khosravan, Balaji Agoram   +11 more
wiley   +1 more source

A probabilistic diagnostic for Laplace approximations: Introduction and experimentation

Canadian Journal of Statistics, Volume 53, Issue 4, December 2025.
Abstract Many models require integrals of high‐dimensional functions: for instance, to obtain marginal likelihoods. Such integrals may be intractable, or too expensive to compute numerically. Instead, we can use the Laplace approximation (LA). The LA is exact if the function is proportional to a normal density; its effectiveness therefore depends on ...
Shaun McDonald, Dave Campbell
wiley   +1 more source

Markers of sudden cardiac death associated with the ventricular-paced 12-lead ECG. [PDF]

Eur Heart J Open
Truyen TTTT, Uy-Evanado A, Nakamura K, Chugh H, Reinier K, Chugh SS.   +5 more
europepmc   +1 more source

Dietary Index for Gut Microbiota and Leisure Time Physical Activity: The Potential Combined Protective Impact on Hypertension Risk

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Joint associations of dietary index for gut microbiota and leisure‐time physical activity with hypertension risk in U.S. adults. ABSTRACT Emerging evidence highlights the gut microbiome's role in hypertension via microbial metabolites and endothelial dysfunction, while the Dietary Index for Gut Microbiota (DI‐GM) quantifies diet quality for microbiota ...
Jiaxin Wang, Xinyi Lu, Yongting Zhao, Zewei Jiang, Jinghao Wang, Zhiguo Wang, Xiaofang Zhang   +6 more
wiley   +1 more source

Torsades de Pointes Triggered by Transient Low-Rate Pacing Following Leadless Pacemaker Implantation. [PDF]

J Arrhythm
Munakata Y, Morita J, Kasai Y, Kitai T, Kondo Y.   +4 more
europepmc   +1 more source

Overview of acute Chinese medicine poisoning in Hong Kong

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 6, December 2025.
Abstract Background Chinese medicine (CM) poisoning is relatively rare in Hong Kong. According to the Department of Health, only 17 cases of self‐medicated Traditional Chinese Medicine (TCM)‐related poisoning were reported between 2019 and 2021—an average of approximately 5.7 cases per year.
Siu Kan Law, Yanping Wang, Xiao Xiao Wu
wiley   +1 more source

Cardiotoxicity of different 5-HT3 receptor antagonists analyzed using the FAERS database and pharmacokinetic study. [PDF]

Sci Rep
Cai Y, Luo S, Lin S, Huang X, Wang X, Yang L, Xu X, Weng X.   +7 more
europepmc   +1 more source

Comparison of Total Intravenous Anesthesia Versus Volatile Anesthesia on Arrhythmia Inducibility and Clinical Outcomes During Catheter Ablation for Ventricular Tachycardia

Journal of Arrhythmia, Volume 41, Issue 6, December 2025.
This study has identified that the maintenance of general anesthesia with TIVA as opposed to volatile anesthesia is associated with increased inducibility of ventricular tachycardia during catheter ablation procedures. 84.5% of TIVA patients were inducible compared to only 15.5%.s ABSTRACT Introduction Catheter ablation is highly efficacious for the ...
Jason Hui, Samual Turnbull, Ashwin Bhaskaran, Saurabh Kumar, Stefan Dieleman   +4 more
wiley   +1 more source