Results 261 to 270 of about 2,113,360 (356)

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

open access: yesScience, 2015
Robert J. A. Bell   +16 more
semanticscholar   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

open access: yesMolecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen   +5 more
wiley   +1 more source

Monitoring circulating tumor DNA by recurrent hotspot mutations in bladder cancer. [PDF]

open access: yesBJC Rep
Tsukahara S   +11 more
europepmc   +1 more source

Understanding TERT Promoter Mutations: A Common Path to Immortality

open access: yesMolecular Cancer Research, 2016
Robert J. A. Bell   +6 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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