Results 241 to 250 of about 795,608 (343)

Discovery of epigenetically silenced tumour suppressor genes in aggressive breast cancer through a computational approach. [PDF]

NAR Cancer
Vitte AL, Chuffart F, Jacquet E, Nika E, Mousseau M, Jung I, Tabone-Eglinger S, Bachelot T, Rousseaux S, Khochbin S, Bourova-Flin E.   +10 more
europepmc   +1 more source

A Novel C19orf47‐AKT2 Chimeric RNA Generated by Cis‐Splicing of Adjacent Genes Is Associated With Glioblastoma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Malignant gliomas pose significant therapeutic challenges. This study aimed to identify and characterize a novel chimeric RNA in glioma and assess its clinical and functional significance for precision treatment. Methods The C19orf47‐AKT2 chimeric RNAs were identified through RNA sequencing and validated by polymerase chain reaction.
Zihan Wang, Bowen Ni, Kezhi Wu, Qi Zhang, Jinglin Guo, Runwei Yang, Ziyu Wang, Guozhong Yi, Guanglong Huang, Minyi He, Yimin Xu, Yawei Liu   +11 more
wiley   +1 more source

Promoter polymorphisms in the JK*01 W.06 allele associated with the Jk(a + ^w) weak antigen phenotype. [PDF]

BMC Immunol
Liang S, Wu F, Jiang R, Liu T, Sun L, Tang R, Dang Y, Deng Z.   +7 more
europepmc   +1 more source

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +1 more source

A promoter library for tuning gene expression in <i>Cupriavidus necator</i> under autotrophic conditions. [PDF]

Front Bioeng Biotechnol
Kitagawa W, Igarashi K, Nagasawa R, Kakizawa S, Horino M, Fujishima K, Fukui T, Kato S.   +7 more
europepmc   +1 more source

Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer

Nature Genetics, 2018
Giulia Orlando, P. Law, A. Cornish, Sara E. Dobbins, D. Chubb, P. Broderick, Kevin Litchfield, F. Hariri, T. Pastinen, Cameron S. Osborne, J. Taipale, R. Houlston   +11 more
semanticscholar   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Haplotype-resolved, gap-free genome assemblies provide insights into the divergence between Asian and European pears. [PDF]

Nat Genet
Sun M, Cao B, Li K, Li J, Liu J, Xue C, Gu K, Xu S, Li Y, Li Q, Qu M, Zhang M, Wang R, Liu Y, Yao C, He H, Wu J.   +16 more
europepmc   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

MAGNETIC: a web server to fetch gene network based on motif distribution in promoters. [PDF]

Nucleic Acids Res
Chakraborty A, Srimali S, Topno R, Ranshur A, Madhusudhan MS.   +4 more
europepmc   +1 more source