Results 141 to 150 of about 924,951 (335)

Promoting geo-education and geotourism through geosite assessment: A case study from Acheron-Parga, Epirus, Greece

open access: yesInternational Journal of Geoheritage and Parks
The regions of Acheron and Parga (Epirus, Greece) are characterized by a significant geodiversity (e.g., stratigraphy, palaeontology, tectonic, geomorphology, hydrology, etc.).
Evangelos Spyrou   +4 more
doaj  

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

RESEARCH ON TOURISM DESTINATIONS MARKETING FROM THE PUBLIC RELATIONS’ PERSPECTIVE

open access: yesRevista de Turism: Studii si Cercetari in Turism, 2012
Nowadays, tourism destinations are more and more determined to build a unique and competitive identity and image in consumers’ minds. Even though the marketing of tourism destinations has been awarded an intended purpose, in practice there is a lack of ...
Gabriela ARIONESEI
doaj  

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

open access: yesMolecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen   +6 more
wiley   +1 more source

Optimal promotions of new products on networks [PDF]

open access: yesarXiv
We present a novel methodology for analyzing the optimal promotion in the Bass model for the spreading of new products on networks. For general networks with $M$ nodes, the optimal promotion is the solution of $2^M-1$ nonlinearly-coupled boundary-value problems.
arxiv  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

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