Results 261 to 270 of about 4,255,836 (340)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of extreme heat on the onset of dementia and all-cause mortality: A 3-year follow-up study in a large population-based cohort in Japan. [PDF]

Alzheimers Dement
Morita A, Nishimura H, Anzai T, Nawa N, Tani Y, Kondo K, Fujiwara T.   +6 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Structural basis of transcription-coupled H3K36 trimethylation by Set2 in coordination with FACT. [PDF]

Sci Adv
Kujirai T, Ehara H, Ito T, Henmi M, Oya E, Kobayashi T, Sekine SI, Kurumizaka H.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Potential profile analysis and influencing factors of physical nurse job embedding. [PDF]

Front Health Serv
Jingjing G, Zhi Z, Yueping C.
europepmc   +1 more source

Parental Low Education, Low Income, Deprivation and School Refusal Among Japanese Elementary School Students in First Grade: Results From A-CHILD Study. [PDF]

Child Care Health Dev
Tokumoto A, Nawa N, Isumi A, Anzai T, Fujiwara T.   +4 more
europepmc   +1 more source

Actions to bridge the workforce and blood supply gaps - Response to "Health promotion for blood donors: A scoping review". [PDF]

Public Health Pract (Oxf)
Wong VW, So NB, Chu CC, Lee CK, Wong JY.
europepmc   +1 more source

FEATURES OF SALES PROMOTION IN RETAIL MARKETS [PDF]

, 2016
Melnuchenko, V., Palekhova, L.
core  

The influence of local officials' promotion incentives on Public-Private Partnership project investment from a political-performance-driven perspective: Empirical evidence from China. [PDF]

PLoS One
Zhang L, Yue M, Du S, Zheng R, Zhu T, Tang B.   +5 more
europepmc   +1 more source