Results 231 to 240 of about 4,804,928 (276)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Prompt engineering-enabled GenAI tools to map the landscape of crosstalk within the gut-brain axis (GBA) and its associated factors. [PDF]

Int J Surg
Chakraborty C, Bhattacharya M, Islam MA.
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Reply to the Letter to the Editor: The role of prompt engineering and referral completeness in evaluating GPT-4 for MRI protocols. [PDF]

Eur Radiol
Terzis R, Kaya K, Pennig L.
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Decoding large language models for radiology: strategies for fine-tuning and prompt engineering. [PDF]

Radiol Adv
Vahdati S, Mahmoudi E, Ganjizadeh A, Chao C, Erickson BJ.   +4 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Diagnostic performance of large language models on the NEJM image challenge: a comparative study with human evaluators and the impact of prompt engineering. [PDF]

Front Med (Lausanne)
Zhou Y, Wang W, Wang P, Hu K.
europepmc   +1 more source

Evaluating the efficacy of large language models in cardio-oncology patient education: a comparative analysis of accuracy, readability, and prompt engineering strategies. [PDF]

Front Artif Intell
Wang Z, Liang L, Xu H, Huang Y, He C, Xu W, Zhu H.   +6 more
europepmc   +1 more source

From prompt engineering to agent engineering: expanding the AI toolbox with autonomous agentic AI collaborators for biomedical discovery. [PDF]

BioData Min
Moore JH, Tatonetti NP.
europepmc   +1 more source