Results 41 to 50 of about 299,609 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Prone Position Impairs Oxygen Supply-Demand Balance During Systemic Hypoxia in Rabbits [PDF]

Ventilation in the prone position improves the prognosis of patients with severe acute respiratory distress syndrome (ARDS). Contraindications to ventilation in this position include unstable systemic circulation.
16774, Takahashi, Shunsaku, 16773, 16772, Funaki, Kazumi, 90403435, 574, 454, ハラダ, トモミ, 3015, オカザキ, ナオト, 高橋, 俊作, 16776, Harada, Tomomi, 16775, 938, 舩木, 一美, Otsuki, Akihiro, イナガキ, ヨシミ, Oshima, Yoshiaki, タカハシ, シュンサク, Okazaki, Naoto, 00379637, 100000092, 30423263, 原田, 知実, オオツキ, アキヒロ, 大槻, 明広, 稲垣, 喜三, フナキ, カズミ, 100000334, Inagaki, Yoshimi, 100000418, 40184717   +33 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dosimetric effects of the supine and prone positions in proton therapy for prostate cancer

Journal of Medical Physics, 2022
Purpose: To quantitatively evaluate how much the doses to organs at risk are affected in the prone position compared to the supine position in the proton therapy (PT) for prostate cancer.
Takahiro Kato, Masato Kato, Kimihiro Takemasa, Masao Murakami   +3 more
doaj   +1 more source

Treatment of ARDS With Prone Positioning [PDF]

Chest, 2017
Prone positioning was first proposed in the 1970s as a method to improve gas exchange in ARDS. Subsequent observations of dramatic improvement in oxygenation with simple patient rotation motivated the next several decades of research. This work elucidated the physiological mechanisms underlying changes in gas exchange and respiratory mechanics with ...
Scholten, Eric L, Beitler, Jeremy R, Prisk, G Kim, Malhotra, Atul   +3 more
openaire   +4 more sources

Factors potentiating the risk of sudden infant death syndrome associated with the prone position

, 1993
Background. In several studies the sudden infant death syndrome (SIDS) has been significantly associated with sleeping in the prone position. It is not known how the prone position increases the risk of SIDS. \ud \ud Methods. We analyzed data from a case-
Jennifer A. Cochrane, Ponsonby, A. L., Wang, You-Gan, Gibbons, L. E., Laura E. Gibbons, You-Gan Wang, Wang, Y. G., Anne-Louise Ponsonby, Cochrane, J. A., Gibbons, Laura E., Ponsonby, Anne-Louise, Terence Dwyer, Cochrane, Jennifer A., Dwyer, T., Dwyer, Terence   +14 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Prolonged prone position in pregnant woman with COVID-19 pneumonia

Journal of Anesthesia, Analgesia and Critical Care, 2022
The manuscript describes a case report of 2 prolonged prone position cycles (72 h each) of a coronavirus disease 2019 pneumonia in an intubated pregnant woman (at 22 weeks of gestational age), being successfully discharged from intensive care unit after ...
Federico Linassi, Matteo Campagnolo, Enrico Busato, Valentina Ortolani, Mario Peta   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source