Results 81 to 90 of about 299,609 (306)

Effectiveness of Prone and Orthopneic Positions on Oxygenation and Respiratory Rate in Isolation Ward Patients

Babali Nursing Research
Background: Patients with respiratory disorders in isolation wards frequently experience hypoxia, and body positioning is a non-invasive strategy to improve oxygenation.
Agus Salim Dali, Sentot Imam Suprapto, Nurwijayanti   +2 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Prone position changes during peak COVID-19 activity on GICU.

, 2023
Chart A shows the total number of prone position changes which occurred on a given day, during the peak period of activity. Chart B shows the relationship between total prone position changes and the times of day at which they occurred.
Ahilanandan Dushianthan (6080540), Alexander I. R. Jackson (17708736), Michael P. W. Grocott (7314398), Sanjay Gupta (106066), Matthew Stubbs (7555751), Rezaur Rahman (15203577), Helmi C. Burton-Papp (17708739), Robert Chambers (7226012), Luke Bracegirdle (12859290)   +8 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Awake prone positioning

Intensive Care Medicine, 2022
Bairbre A. McNicholas, Stephan Ehrmann, John G. Laffey   +2 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The mechanical power of prone ventilation

Journal of Mechanical Ventilation
Prone ventilation has been shown to reduce mortality in moderate to severe acute respiratory distress syndrome (ARDS) by enhancing oxygenation, improving lung mechanics, and reducing ventilator-induced lung injury.
Ryan Thomas Lee, John Christian Widere
doaj   +1 more source

Prone Position

, 2015
Prone positioning, first proposed in 1974 and first applied in ARDS patients in 1976, results in improved arterial oxygenation in most patients. After the introduction of CT scanning, showing lung consolidation located in the dependent lung regions and ...
L. Gattinoni
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source