Results 121 to 130 of about 167,450,031 (235)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

A Hybrid ABAC–RpBAC Framework for Enhancing PoS Consensus Against Sybil Attacks

Future Internet
Sybil attacks remain a primary challenge for Proof-of-Stake (PoS) blockchain systems, as low-cost identity creation can distort validator participation and limit consensus reliability.
Mohammed Al Qurashi, Ibtihaj Al Qarni
doaj   +1 more source

Absorption of Broadband Low‐Frequency Sound Beyond the Thermodynamics Limit: An Acoustic Resonator With Magnetic Bearing

Advanced Science, EarlyView.
This work presents a magnetic‐bearing acoustic resonator that overcomes the thermodynamics limit of sound absorption. By introducing tunable negative stiffness, it achieves broadband low‐frequency absorption within a compact cavity, far exceeding the performance achievable by classic mass‐tuned designs.
Ying Hu, Zhe Zhang, Bohua Huang, Xue Han, Hallam Bastin Kilcoyne, Lixi Huang   +5 more
wiley   +1 more source

Non-Compensatory Security and Utility Gates for Blockchain Lifecycle Assessment: Framework Development and an Operational-Energy Application to the Ethereum Merge

Applied Sciences
Environmental comparisons of blockchain systems are often reduced to electricity per transaction, although operational services also depend on validators, cloud gateways, storage, monitoring, key management, recovery, and hardware replacement. This study
Nikolay Hinov
doaj   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

METHOD FOR ASSESSING COMMITTEE-CAPTURE RISK UNDER STAKE CONCENTRATION IN PROOF-OF-STAKE

This paper studies committee selection in committee-based Proof-of-Stake networks under increasing stake concentration. The problem is how to assess committee-capture risk, that is, the probability that a monitored coalition obtains a capturing share of ...
I. R. Solomka, B. B. Liubinskyi
core   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Thermally Assisted Photocatalytic Dehydrogenation of Methanol in Continuous Steady‐State Operation

Advanced Science, EarlyView.
Thermally assisted photocatalytic methanol dehydrogenation on Pt/TiO2 enables formaldehyde and hydrogen production far beyond thermodynamic limits. Continuous operation delivers up to 95% selectivity over 70 h, and oxygen microdosing strongly boosts conversion by regenerating surface oxygen sites.
Florian Stubenrauch, Phillip Nathrath, Markus Schörner, Yazan Mahayni, Birk Fritsch, Andreas Hutzler, Peter Wasserscheid, Andreas Bösmann, Patrick Schühle   +8 more
wiley   +1 more source

Design of Photocatalytic Composite Coatings for Formaldehyde Removal Based on the Visual Effects of Wood Furniture

Advanced Science, EarlyView.
This work develops photocatalytic coatings for indoor formaldehyde removal on wood surfaces. It explores coating‐induced color variations and visual perception via eye‐tracking tests. Combined with XGBoost and Bayesian optimization, an intelligent design framework is established to guide the optimization of visually friendly wood photocatalytic ...
Xinyue Wei, Shuyuan Chen, Xinlong Zhou, Han Wang, Wei Guo, Xiaoting Niu, Wei Li, Zhen Ding, Haiyuan Chi   +8 more
wiley   +1 more source

Robust Stitching Interface and Deep Learning Empowered Hydrogel Human‐Machine Interface

Advanced Science, EarlyView.
A molecular design strategy is presented that exploits synergistic carboxylate anion–quaternary ammonium interactions to simultaneously strengthen the hydrogel–PET interface and the bulk hydrogel network. Integrated with deep learning signal processing, the stable hydrogel–PET interface enables consistent signal acquisition and reliable human‐machine ...
Hao Dong, Yiming Luo, Chuanliu Liu, Mahamood Modupe Rasheedat, Wenjiayi Tan, Fangyu Zhao, Yixue Zhang, Chris Connor, Hua Hou, Hamdy Khamees Thabet, Ben Bin Xu, Huige Wei   +11 more
wiley   +1 more source