Results 31 to 40 of about 167,450,031 (235)

DPoSEB: Delegated Proof of Stake with Exponential Backoff Consensus Algorithm for Ethereum Blockchain [PDF]

Computer Science Journal of Moldova
Blockchain is a technology that is rapidly gaining prominence and finding applications in various sectors such as banking, supply chain, healthcare, and e-governance.
Narayan D. G., Naveen Arali, R. Tejas
doaj   +1 more source

From permissioned to proof-of-stake consensus [PDF]

This paper presents the first generic compiler that transforms any permissioned consensus protocol into a proof-of-stake permissionless consensus protocol. For each of the following properties, if the initial permissioned protocol satisfies that property
Lewis-Pye, Andrew, Neu, Joachim, Nusret Tas, Ertem, Tas, Ertem Nusret, Komatovic, Jovan, Roughgarden, Tim   +5 more
core   +5 more sources

Formal Barriers to Longest-Chain Proof-of-Stake Protocols

, 2019
The security of most existing cryptocurrencies is based on a concept called Proof-of-Work, in which users must solve a computationally hard cryptopuzzle to authorize transactions ("one unit of computation, one vote'').
Weinberg, Seth M, Psomas, Alexandros,, Arvind Narayanan, Brown-Cohen, Jonah,, S. Matthew Weinberg, Alexandros Psomas, Brown-Cohen, Jonah, Narayanan, Arvind, Jonah Brown-Cohen, Psomas, Alexandros, Weinberg, S. Matthew,, Narayanan, Arvind,   +11 more
core   +1 more source

Analysis of Blockchain consensus mechanisms : Proof-of-Work vs Proof-of-Stake [PDF]

, 2022
The objective of this thesis is to understand and evaluate the two popular consensus mechanisms of blockchain: Proof-of-Work (PoW) and Proof-of-Stake (PoS), especially in terms of their cost effectiveness.
Saif, Saba
core  

Game-Theoretic Randomness for Proof-of-Stake

, 2023
Many protocols in distributed computing rely on a source of randomness, usually called a random beacon, both for their applicability and security. This is especially true for proof-of-stake blockchain protocols in which the next miner or set of miners ...
Goharshady, Amir, Cai, Zhuo
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Coin concentration of Proof-of-Stake blockchains [PDF]

, 2023
This paper studies the concentration of block production in selected Proof-of-Stake (PoS) blockchains and finds evidence consistent with participants entering and leaving the consensus process, thereby changing the concentration level, but not with ...
Ruomei Yang, Yang, R, Yang, Ruomei, Irresberger, F, Felix Irresberger, Irresberger, Felix   +5 more
core   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Impact of Saving Attacks on Blockchain Consensus

IEEE Access, 2021
Blockchain consensus, which enables nodes on a peer-to-peer network to agree on the same ledger history, is the core element of blockchain systems. In many blockchain systems, a node chosen as a block proposer, in accordance with the consensus protocol ...
Kai Otsuki, Ryuya Nakamura, Kazuyuki Shudo   +2 more
doaj   +1 more source