Results 41 to 50 of about 4,199,573 (346)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A numerical investigation of constant-volume non-Boussinesq density currents [PDF]

open access: yes, 2010
The time-dependent behaviour of non-Boussinesq high-Reynolds-number density currents of density ρc, released from a lock of height h₀ and length x₀ into a ambient of height H and density ρₐ, is considered. We use two dimensional Navier-Stokes simulations
Ungarish, Marius   +2 more
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

The effect of the gravitational constant variation on the propagation of gravitational waves

open access: yesPhysics Letters B, 2023
Since the first detection of gravitational waves, they have been used to investigate various fundamental problems, including the variation of physical constants.
Jiachen An   +4 more
doaj   +1 more source

Generalized Constant Propagation a study in C [PDF]

open access: yes, 1996
Generalized Constant Propagation (GCP) statically estimates the ranges of variables throughout a program. GCP is a top-down compositional compiler analysis in the style of abstract intepretation. In this paper we present an implementation of both intraprocedural and interprocedural GCP within the context of the C language.
Clark Verbrugge   +2 more
openaire   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Characterizing the variation of propagation constants in multicore fiber

open access: yesOptics Express, 2014
We demonstrate a numerical technique that can evaluate the core-to-core variations in propagation constant in multicore fibre. Using a Markov Chain Monte Carlo process, we replicate the interference patterns of light that has coupled between the cores during propagation.
Peter J. Mosley   +5 more
openaire   +3 more sources

Flow-Sensitive Interprocedural Constant Propagation

open access: yes, 1995
We present a flow-sensitive interprocedural constant propagation algorithm, which supports recursion while only performing one flow-sensitive analysis of each procedure. We present experimental results which show that this method finds substantially more
Paul R. Carini, Michael Hind
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

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