Results 41 to 50 of about 61,471 (312)
Infigratinib in children with achondroplasia: the PROPEL and PROPEL 2 studies
Therapeutic Advances in Musculoskeletal Disease, 2022 Background: Achondroplasia is the most common short-limbed skeletal dysplasia resulting from gain-of-function pathogenic variants in fibroblast growth factor receptor 3 ( FGFR3) gene, a negative regulator of endochondral bone formation. Most treatment options are symptomatic, targeting medical complications.
Savarirayan, Ravi +25 more
openaire +10 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak +4 more
wiley +1 more source
, 1978 A case bonded end burning solid propellant rocket motor is described. A propellant with sufficiently low modulus to avoid chamber buckling on cooling from cure and sufficiently high elongation to sustain the stresses induced without cracking is used. The
Marsh, H. E., Jr., Shafer, J. I.
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Determining the major propellants of I.R. Iran’s defensive diplomacy in regional and international levels [PDF]
آیندهپژوهی دفاعی, 2016 Defensive Diplomacy is a part of government policy which plays role as an important tool in achieving the major objectives of the armed forces and its purpose can be considered to develop favorable national and international political conditions for ...
Hossein Minaee +3 more
doaj
Attitude and propellant flow control system and method Patent [PDF]
, 1962 Attitude and propellant flow control system for liquid propellant rocket ...
Escher, W. J. D.
core +1 more source
Arthritis Care &Research, EarlyView.Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu +2 more
wiley +1 more source
Xibei Gongye Daxue Xuebao, 2022 Aiming at the structural response characteristics of solid rocket motor (SRM) under vertical storage conditions, the creep tests of HTPB propellant under different stress levels were carried out, and the creep constitutive model of the propellant was ...
CHEN Ke +4 more
doaj +1 more source
Numerical Modeling of Tank Cars Carrying Hazardous Materials With and Without Composite Metal Foam
Advanced Engineering Materials, EarlyView.Large‐scale puncture models consisting of hazardous materials (HAZMATs) tank car with protective steel–steel composite metal foam (S–S CMF) are solved numerically. Tank car plate with added 10.91–13.33 mm thick S–S CMF layer does not puncture. Protective S–S CMF absorbs impact energy, reduces plate deformation, and prevents shear bands formation ...
Aman Kaushik, Afsaneh Rabiei
wiley +1 more source
Cryogenic propellant management in space: open challenges and perspectives
npj MicrogravityThis paper presents open challenges and perspectives of propellant management for crewed deep space exploration. The most promising propellants are liquid hydrogen and liquid methane, together with liquid oxygen as an oxidizer. These fluids remain liquid
Alessia Simonini +9 more
doaj +1 more source