Results 41 to 50 of about 59,601 (294)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Unsteady Aerodynamic Investigation of the Propeller-Wing Interaction for a Rocket Launched Unmanned Air Vehicle

open access: yesAdvances in Mechanical Engineering, 2013
The aerodynamic characteristics of propeller-wing interaction for the rocket launched UAV have been investigated numerically by means of sliding mesh technology.
G. Q. Zhang   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Propeller-activated resonances and the fate of short-period cataclysmic variables

open access: yes, 2006
We show that the combination of a weak magnetic propeller and accretion disc resonances can effectively halt accretion in short-period cataclysmic variables (CVs) for large fractions of their lifetimes.
P. J. Wheatley (7590065)   +3 more
core   +5 more sources

Numerical investigation of the unsteady flow of a hybrid CRP pod propulsion system at behind-hull condition

open access: yesInternational Journal of Naval Architecture and Ocean Engineering, 2020
Flows induced by hybrid CRP pod propulsion systems (CRP-POD) are fundamentally characterized by unsteadiness. This work presents a numerical study on the unsteady flow of a CRP-POD at behind-hull condition based on CFD (Computational Fluid Dynamics ...
Yuxin Zhang, Xuankai Cheng, Liang Feng
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

open access: yesFEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia   +9 more
wiley   +1 more source

Numerical propeller rudder interaction studies to assist fuel efficient shipping

open access: yes, 2012
Reducing the fuel consumption of shipping presents opportunities for both economic and environmental gain. From a resistance and propulsion standpoint, a more holistic propeller/hull/rudder interaction strategy has the potential to reduce fuel ...
Badoe, C., Turnock, S.R., Phillips, A.B.
core   +1 more source

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