Results 151 to 160 of about 3,722,033 (368)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Farm Level Analysis of the Economic Impact of the MARENA Program in Honduras [PDF]

Impact Evaluation, Propensity Score Matching, Fixed Effects, Internal Rate of Return, Technical Efficiency, Honduras, International Development,
Bravo-Ureta, Boris E., de Almeida, Alexandre, Inestroza, Aaron, Solis, Daniel   +3 more
core   +1 more source

Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study

Nature Medicine, 2020
Sean T. H. Liu, Hung-mo Lin, Ian Baine, A. Wajnberg, J. Gumprecht, F. Rahman, Denise Rodriguez, P. Tandon, A. Bassily-Marcus, J. Bander, Charles Sanky, A. Dupper, Allen Zheng, Freddy T. Nguyen, F. Amanat, D. Stadlbauer, D. Altman, Benjamin K. Chen, F. Krammer, D. R. Mendu, A. Firpo-Betancourt, M. Levin, E. Bagiella, A. Casadevall, C. Cordon-Cardo, J. Jhang, S. Arinsburg, D. Reich, J. Aberg, Nicole M. Bouvier   +29 more
semanticscholar   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A propensity score analysis of public incentives: The Italian case [PDF]

Public support to firms has been a traditional and important industrial policy measure in many countries for several decades. One of the reasons for public intervention is the existence of market failures or imperfections.
Affuso, Antonio
core   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Minimizing Bias in Selection on Observables Estimators When Unconfoundness Fails [PDF]

We characterize the bias of propensity score based estimators of common average treatment effect parameters in the case of selection on unobservables. We then propose a new minimum biased estimator of the average treatment effect.
Millimet, Daniel L., Tchernis, Rusty
core  

The central role of the propensity score in observational studies for causal effects

, 1983
P. Rosenbaum, Donald B. Rubin
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

PSAgraphics: An R Package to Support Propensity Score Analysis [PDF]

Propensity score analysis is a technique for adjusting for selection bias in observational data. Estimated propensity scores (probability of treatment given observed covariates) are used for stratification of observations. Within strata covariates should
James E. Helmreich, Robert M. Pruzek
core   +1 more source