Results 81 to 90 of about 206,310 (335)

Five Steps to Successfully Implement and Evaluate Propensity Score Matching in Clinical Research Studies

Anesthesia and Analgesia, 2018
In clinical research, the gold standard level of evidence is the randomized controlled trial (RCT). The availability of nonrandomized retrospective data is growing; however, a primary concern of analyzing such data is comparability of the treatment ...
S. Staffa, D. Zurakowski
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Transarterial Chemoembolization for Patients With Hepatocellular Carcinoma Using Miriplatin Without the Need for Hydration

Clinical and Translational Science
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with a rising incidence. The most common therapeutic choice for HCC is transarterial chemoembolization (TACE). While the standard protocol of TACE adopts cisplatin, the application
Koji Fujita, Kei Takuma, Kyoko Oura, Tomoko Tadokoro, Asahiro Morishita, Takashi Himoto, Hideki Kobara   +6 more
doaj   +1 more source

A Case Study About Why It Can Be Difficult To Test Whether Propensity Score Analysis Works in Field Experiments

Journal of Methods and Measurement in the Social Sciences, 2013
Peikes, Moreno and Orzol (2008) sensibly caution researchers that propensity score analysis may not lead to valid causal inference in field applications.
William R. Shadish, Peter M. Steiner, Thomas D. Cook   +2 more
doaj   +1 more source

Adoption of rainwater harvesting and its impact on smallholder farmer livelihoods in Kutaber district, South Wollo Zone, Ethiopia

Cogent Food & Agriculture, 2020
This study aimed to identify determinants of rainwater harvesting adoption, and evaluate its impact on livelihood of smallholder farmers in Kutaber district. A multi-stage sampling technique was employed to select 196 sample households.
Zenebe Kelemewerk Mekuria, Andualem Kassegn Amede, Ebrahim Endris Mekonnen   +2 more
doaj   +1 more source

Preoperative malnutrition with mild hypoalbuminemia associated with postoperative mortality and morbidity of colorectal cancer: a propensity score matching study

Nutrix Journal, 2019
BackgroundMalnutrition with hypoalbuminemia (albumin  = 35 g/L). Significant differences were noted in 21 clinical characteristics between the two groups.
Wan-Hsiang Hu, Samuel Eisenstein, Lisa A. Parry, S. Ramamoorthy   +3 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies

Multivariate Behavioral Research, 2011
The propensity score is the probability of treatment assignment conditional on observed baseline characteristics. The propensity score allows one to design and analyze an observational (nonrandomized) study so that it mimics some of the particular ...
P. Austin
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Gifted and Talented Services for EFL Learners in China: A Step-by-Step Guide to Propensity Score Matching Analysis in R

Data, 2019
We sought to quantify the effectiveness of a gifted and talented (GT) program, as was provided to university students who demonstrated a talent for learning English as a foreign language (EFL) in China.
Shifang Tang, Fuhui Tong, Xiuhong Lu
doaj   +1 more source