Results 91 to 100 of about 2,388,514 (295)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Functional brain asymmetry and the proper name [PDF]
, 2012 There are several published works on the influence of long-term weak acoustic stimuli onto living organisms and their development. In this context, functional brain asymmetry (FBA) parameters were studied in correlation with the proper name. A. R.
Volchek, Olga D.
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Imię Cyryl w antroponimii historycznej Brańska i okolic
Zeszyty Cyrylo-Metodiańskie, 2018 The Proper Name Cyril in the Historical Anthroponymy of Bransk and Its Surrounding Area. The paper offers an attempt to answer the question of the presence of onymic structures containing the proper name Cyril in the local historical anthroponymic ...
Złotkowski, Piotr
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Pet Naming Practices in Turkey
NamesPet-naming practices reflect the attitudes of pet owners towards their pets and their place in their lives and society. In the US and other western countries, pet animals are often given names that are commonly used for humans.
F. Nihan Ketrez
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Nickname as Special Type of Onym: in Search of Integrated Sign
Известия Южного федерального университета: Филологические науки, 2018 Nicknames (network names) form special onomastic system which on the level of community and differentiation is comparable to the system of traditional personal names, but possesses a special arsenal of pragmatical, formal, grammatical, semantic and ...
Anastasia V. Zubareva
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
On the nature of proper names and definite descriptions from a cognitive perspective
Bucharest Working Papers in Linguistics, 2007 In the present study, I present an analysis of proper names and definite descriptions based on Machery et al. (2004), in the treatment of Petho (2005a), which I revisit by pointing at several theoretical aspects not detailed or not mentioned by Petho ...
Agota Osz
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