Results 191 to 200 of about 6,751,316 (288)

Is Persistence a Hazard? [PDF]

Environ Sci Technol
Scheringer M, Cousins IT.
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

PlasRAG: comprehensive plasmid characterization and retrieval through sequence-text alignment. [PDF]

Genome Biol
Ji Y, Guan J, Liao H, Shang J, Sun Y.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Steering semi-flexible molecular diffusion model for structure-based drug design with reinforcement learning. [PDF]

Sci Adv
Zhang X, Qu S, Lu F, Wang J, Tian Z, Gu S, Zhang Y, Knoll A, Gao S, Chen G, Jiang C.   +10 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Emex spinosa (L.) Campd.: A Review on Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Profile. [PDF]

Chem Biodivers
Amtaghri S, Olofinsan K, Okumu MO, Mokhetho KC, Iqbal S, Mangoato IM, Amtaghri M, Lamtai M, Brouzi MYE, Matsabisa MG.   +9 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

AI-Assisted Design of Chemically Recyclable Polymers for Food Packaging. [PDF]

Polymers (Basel)
Phan BK, Kim C, Nistane J, Xiong W, Chen H, Jang WJ, Gholami F, Su Y, Qi J, Lively R, Gutekunst W, Ramprasad R.   +11 more
europepmc   +1 more source