Results 181 to 190 of about 10,099,236 (261)

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

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Psychometric Properties of the HEXACO Personality Inventory

Multivariate Behavioral Research, 2004
We introduce a personality inventory designed to measure six major dimensions of personality derived from lexical studies of personality structure. The HEXACO Personality Inventory (HEXACO-PI) consists of 24 facet-level personality trait scales that define the six personality factors named Honesty-Humility (H), Emotionality (E), Extraversion (X ...
Kibeom, Lee, Michael C, Ashton
openaire   +2 more sources

Psychometric properties of the wife abuse inventory

Journal of Clinical Psychology, 1990
It is estimated that approximately 50% of all married couples experience violence during their relationship (Lewis, 1985). The present study (N = 305) investigated the psychometric properties of the Wife Abuse Inventory (WAI), which was designed to identify women at risk for abuse.
G M, Poteat, W F, Grossnickle, J G, Cope, D C, Wynne   +3 more
openaire   +2 more sources

The Reasons for Living Inventory: Psychometric Properties

Psychological Reports, 1991
The test-retest reliability, internal consistency reliability, normative, and item analysis data of the Reasons for Living Inventory were investigated in a sample of 116 college students. The inventory has six subscales, each of which assesses a category of adaptive beliefs and expectations considered reasons for not committing suicide.
A, Osman, K, Jones, J R, Osman
openaire   +2 more sources

The Panic Appraisal Inventory: Psychometric properties

Behaviour Research and Therapy, 1997
We examined the reliability and validity of the Panic Appraisal Inventory (PAI) in a sample of 47 outpatients with DSM-III-R panic disorder. Results showed excellent internal consistency and treatment sensitivity. We found good convergent validity; divergent validity vis-a-vis depression and social adjustment was adequate.
U, Feske, E, de Beurs
openaire   +2 more sources

On Properties of Stochastic Inventory Systems

Management Science, 1992
For most order quantity/reorder point inventory systems, the stochastic model, which specifies the demands as stochastic processes, is often more accurate than its deterministic counterpart—the EOQ model. However, the application of the stochastic model has been limited because of the absence of insightful analytical results on the model.
openaire   +1 more source

Landslide inventories and their statistical properties

Earth Surface Processes and Landforms, 2004
AbstractLandslides are generally associated with a trigger, such as an earthquake, a rapid snowmelt or a large storm. The landslide event can include a single landslide or many thousands. The frequency–area (or volume) distribution of a landslide event quantifies the number of landslides that occur at different sizes.
Malamud BD, Turcotte DL, Guzzetti F, Reichenbach P   +3 more
openaire   +4 more sources