Results 51 to 60 of about 10,099,236 (261)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Development of a brownfield inventory for prioritizing funding outreach in Tucson, Arizona

Geo-spatial Information Science, 2021
Fear of liability from the 1980 Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA or Superfund) has prompted developers to build preferentially upon undeveloped green space rather than potentially contaminated former ...
Theresa Foley, Ann Marie Wolf, Chloe Jackson, Ryan Stephenson   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Psychometric Properties of the Mini-Social Phobia Inventory

The Primary Care Companion to The Journal of Clinical Psychiatry, 2009
Although a potentially useful measure, to date, there has been only one published test of the psychometric properties of the Mini-Social Phobia Inventory (Mini-SPIN). Therefore, the psychometric properties of the Mini-SPIN, a brief 3-item screen for social anxiety disorder, were examined.Participants were 186 patients diagnosed with social anxiety ...
Elizabeth, Seeley-Wait, Maree J, Abbott, Ronald M, Rapee   +2 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Landslide susceptibility mapping and similar case matching based on case library: a case study of Xinjing landslide, China

Geomatics, Natural Hazards & Risk
Landslide susceptibility mapping (LSM) predicts potential landslide risks based on historical landslides, playing a crucial role in landslide prevention and control.
He Wang, Tianhong Yang, Yixuan Wang, Yong Zhao, Peng Niu, Penghai Zhang   +5 more
doaj   +1 more source

“Glass of Optics” as a Means of Understanding the World in the Poem by G. R. Derzhavin “To Eugene. Life in Zvanka” [PDF]

Достоевский и мировая культура: Филологический журнал
The article aims to identify the empirical foundations of the cosmic imagery of G. R. Derzhavin’s poetry and to reveal the mechanisms for transforming visible pictures of the Universe in the poem “To Eugene.
Ksenia A. Potashova
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

THE CONTRIBUTIONS OF IVAN IV AND THE PRINCES PALETSKY TO THE KIRILLO-BELOZERSKY MONASTERY: POWER AND MEMORY

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. The scientific literature shows that the Kirillo-Belozersky Monastery was large and significant in medieval Russia. Scientists have repeatedly addressed the study of contributions and the social composition of contributors to this ...
Nikita Bashnin
doaj   +1 more source