Results 121 to 130 of about 24,229,753 (306)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Poly(butylene adipate-co-terephthalate) (PBAT)/AgFe2O4 biopolymer nanocomposite-based flexible triboelectric nanogenerator as a self-powered touch sensor

eXPRESS Polymer Letters
Triboelectric nanogenerators (TENGs) offer a promising solution for self-powered sensor applications, but their viability depends on cost-effective and efficient designs.
Vishnu Kadabahalli Thammannagowda, Kariyappa Gowda Guddenahalli Shivanna, Smitha Ankanahalli Shankaregowda, Stéphane Panier, Prashantha Kalappa   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

JQF: coverage-guided property-based testing in Java

International Symposium on Software Testing and Analysis, 2019
We present JQF, a platform for performing coverage-guided fuzz testing in Java. JQF is designed both for practitioners, who wish to find bugs in Java programs, as well as for researchers, who wish to implement new fuzzing algorithms.
Rohan Padhye, Caroline Lemieux, Koushik Sen   +2 more
semanticscholar   +1 more source

The psychometric property testing of creativity disposition scale among basic education students

Acta Psychologica
Creativity disposition encompasses emotional and motivational traits that facilitate creative engagement and contribute to success in innovative endeavors.
Weeraphol Saengpanya, Ratchaneekorn Upasen, Somkiat Kaewkohsaba, Sirirut Jumnaksarn   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Variability and Evaluation Method of Recycled Concrete Aggregate Properties

Advances in Materials Science and Engineering, 2017
With the same sources and regeneration techniques, given RA’s properties may display large variations. The same single property index of different sets maybe has a large difference of the whole property.
Zhiqing Zhang, Bozhao Shen, Hui Ren, Jin Wang, Shiyun Li, Hao Liu   +5 more
doaj   +1 more source