Results 51 to 60 of about 403,714 (266)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Linking unit tests and properties [PDF]

Proceedings of the 14th ACM SIGPLAN Workshop on Erlang, 2015
QuickCheck allows us to verify software against particular proper- ties. A property can be regarded as an abstraction over many unit tests. QuickCheck uses generated random input data to test such properties. If a counterexample is found, it becomes immediately clear what we have tested.
Gerdes, Alex, Hughes, John, Smallbone, Nick, Wang, Meng   +3 more
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Testing Polymorphic Properties [PDF]

, 2010
This paper is concerned with testing properties of polymorphic functions. The problem is that testing can only be performed on specific monomorphic instances, whereas parametrically polymorphic functions are expected to work for any type. We present a schema for constructing a monomorphic instance for a polymorphic property, such that correctness of ...
Jean-Philippe Bernardy, Patrik Jansson, Koen Claessen   +2 more
openaire   +1 more source

Hierarchy Theorems for Property Testing [PDF]

computational complexity, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Goldreich, Oded, Krivelevich, Michael, Newman, Ilan, Rozenberg, Eyal   +3 more
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Evaluation on the Adhesion Property of Recycled Asphalt Based on the Multi-Scale Experiments

Buildings
The adhesion property has consistently been a critical focus in the utilization of recycled asphalt (RA). This research aimed to elucidate the mechanisms influencing the adhesion property of RA at various scales.
Peng Yin, Fei Liu, Zihan Li, Baofeng Pan, Tao Liu   +4 more
doaj   +1 more source

Testing Liveness Properties [PDF]

, 2006
Satisfaction within fairness establishes an abstract notion of truth under fairness in linear-time verification. It can be argued that the idea of an implementation meeting the intersection of the system behaviour and the requirement specification forms a desirable basis for testing systems.
Ulrich Ultes-Nitsche, Simon St James
openaire   +1 more source