Results 81 to 90 of about 24,229,753 (306)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Non-Deterministic Graph Property Testing [PDF]
Combinatorics, Probability and Computing, 2013 A property of finite graphs is called non-deterministically testable if it has a ‘certificate’ such that once the certificate is specified, its correctness can be verified by random local testing. In this paper we study certificates that consist of one or more unary and/or binary relations on the nodes, in the case of dense graphs.
L. Lovxe1sz, K. Vesztergombi
openaire +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Testing local properties of arrays
CoRR, 2018 We study testing of local properties in one-dimensional and multi-dimensional arrays. A property of $d$-dimensional arrays $f:[n]^d \to Σ$ is $k$-local if it can be defined by a family of $k \times \ldots \times k$ forbidden consecutive patterns. This definition captures numerous interesting properties.
openaire +5 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Evaluation on the Adhesion Property of Recycled Asphalt Based on the Multi-Scale Experiments
BuildingsThe adhesion property has consistently been a critical focus in the utilization of recycled asphalt (RA). This research aimed to elucidate the mechanisms influencing the adhesion property of RA at various scales.
Peng Yin +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Parameterized Property Testing of Functions
Electron. Colloquium Comput. Complex., 2017 We investigate the parameters in terms of which the complexity of sublinear-time algorithms should be expressed. Our goal is to find input parameters that are tailored to the combinatorics of the specific problem being studied and design algorithms that ...
R. Pallavoor +2 more
semanticscholar +1 more source