Results 41 to 50 of about 14,690 (240)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Prophylactic onlay mesh at emergency laparotomy: promising early outcomes with long‐acting synthetic resorbable mesh

ANZ Journal of Surgery, 2022
AbstractBackgroundCareful surgical strategy is paramount in balancing the prevention of fascial dehiscence, incisional hernia (IH) and fear of additional mesh‐related wound complications post‐laparotomy. This study aims to review early outcomes of patients undergoing an emergency laparotomy with prophylactic TIGR® mesh, used to reduce early fascial ...
Daniah Alsaadi, Ian Stephens, Lydia O. Simmons, Magda Bucholc, Michael Sugrue   +4 more
openaire   +2 more sources

Prophylactic Mesh in Primary Stoma Formation to Prevent Parastomal Hernia: A Systematic Review and Meta-Analysis of its Risk and Benefit

Dr. Sulaiman Al Habib Medical Journal
More than 50% of patients living with a stoma will develop a parastomal hernia. Despite many controversies, the use of prophylactic mesh during primary stoma formation is promising.
Citra Aryanti, Erwin Syarifuddin, Julianus A. Uwuratuw   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Prophylactic mesh placement for the PREvention of paraSTOmal hernias: The PRESTO systematic review and meta-analysis. [PDF]

PLoS ONE, 2017
BACKGROUND:Parastomal hernia (PH) is the most common complication after ostomy formation. Prophylactic mesh placement may be effective in reducing the rate of PH at the stoma site.
Frank Pianka, Pascal Probst, Anne-Valerie Keller, Daniel Saure, Kathrin Grummich, Markus W Büchler, Markus K Diener   +6 more
doaj   +1 more source

Delayed Hypersensitivity Reaction to Titanium-coated Polypropylene Mesh in Breast Reconstruction

Plastic and Reconstructive Surgery, Global Open, 2022
Summary:. Breast implant reconstructions increasingly incorporate meshes like the synthetic nonresorbable titanium-coated polypropylene mesh commercialized as Tiloop (Pfm medical).
Eva Jouve, MD, Françoise Giordano-Labadie, MD, Gabrielle Selmes, MD, Marc Soule-Tholy, MD, Anne-Sophie Navarro, MD, Dimitri Gangloff, MD, Thomas Meresse, MD, Raphaelle Duprez-Paumier, MD, Emilie Tournier, MD, Charlotte Vaysse, PhD, MD   +9 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prevention of a parastomal hernia by biological mesh reinforcement

Frontiers in Surgery, 2015
Introduction: In the field of hernia prevention the prophylactic mesh-reinforcement of stoma-sites is one of the most controversially discussed issues. The incidence of parastomal hernias in the literature reported to be up to 48.1% after end colostomy ...
René H Fortelny, Anna eHofmann, Christopher eMay, Ferdinand eKöckerling   +3 more
doaj   +1 more source

Safety and aesthetic outcomes of SERASYNTHⓇ MESH BR for direct-to-implant breast reconstruction: A retrospective single center analysis of 32 consecutive cases

JPRAS Open, 2023
Background: Bilateral mastectomy for both therapeutic and prophylactic reasons is becoming increasingly important. To achieve good results after mastectomy, synthetic meshes are often used as an alternative to acellular dermal matrices (ADMs). The aim of
Julia Gruber, Paul Schlagnitweit, Georgios Koulaxouzidis   +2 more
doaj   +1 more source