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Der Anaesthesist, 2004
Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J. Roggenbach, Johann Motsch
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Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J. Roggenbach, Johann Motsch
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Propofol Is a Peroxynitrite Scavenger
Anesthesia & Analgesia, 1997P eroxynitrite is a potent oxidant formed by the rapid reaction between nitric oxide and superoxide radical (1). The peroxynitrite anion is relatively stable, but it can rapidly protonate to peroxynitrous acid, an unstable species, which decomposes with a half-life of about one second at pH 7.4 (1,2).
Demiryurek, AT, Kahraman, S
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Techniques in Gastrointestinal Endoscopy, 2009
Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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Anesthesiology, 2005
Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for human use. Because of the occurrence of Cremophor EL anaphylaxis and improvements in the quality of lipid emulsions, it was ultimately brought to market as 1% propofol formulated in 10% soybean oil emulsion.
Max T. Baker +2 more
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Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for human use. Because of the occurrence of Cremophor EL anaphylaxis and improvements in the quality of lipid emulsions, it was ultimately brought to market as 1% propofol formulated in 10% soybean oil emulsion.
Max T. Baker +2 more
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Propofol use for sedation or sedation for propofol use?
Journal of Anesthesia, 2011A large amount of pharmacological and clinical evidence supports the abuse potential of propofol. Although previous case reports have indicated that recreational use of propofol is primarily by medical professionals, its spread among the general public has recently been highlighted.
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International Anesthesiology Clinics, 2011
Ethan O, Bryson, Elizabeth A M, Frost
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Ethan O, Bryson, Elizabeth A M, Frost
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