Results 351 to 360 of about 213,484 (400)
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2008
The hypnotic agent propofol has pharmacokinetic characteristics that allow for rapid onset and offset of drug effect and fast elimination from the body. Elderly patients show a greater sensitivity to the hypnotic effect of propofol. The drug is extensively metabolized in the liver through the cytochrome P450 system and glucuronidation, with potential ...
Vanlersberghe, C., Camu, Fréderic
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The hypnotic agent propofol has pharmacokinetic characteristics that allow for rapid onset and offset of drug effect and fast elimination from the body. Elderly patients show a greater sensitivity to the hypnotic effect of propofol. The drug is extensively metabolized in the liver through the cytochrome P450 system and glucuronidation, with potential ...
Vanlersberghe, C., Camu, Fréderic
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European Journal of Anaesthesiology, 2019
BACKGROUND Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most complex gastrointestinal endoscopic procedures. Currently, it is still unclear which sedation regimen best facilitates an ERCP.
S. Eberl +6 more
semanticscholar +1 more source
BACKGROUND Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most complex gastrointestinal endoscopic procedures. Currently, it is still unclear which sedation regimen best facilitates an ERCP.
S. Eberl +6 more
semanticscholar +1 more source
Propofol and the electroencephalogram
Clinical Neurophysiology, 2010Propofol is an emulsion formulation of 2,6 diisopropylphenol developed in 1975. Widely recognized, it offers beneficial effects compared with other sedative drugs. Propofol is used in several clinical situations including multiple surgical procedures and critical-care medical conditions.
Andrew J. Cole +2 more
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Critical Care Medicine, 2019
Objectives: Propofol-based sedation may increase hemodynamic instability by decreasing vascular tone and venous return. Incremental exogenous catecholamines doses may be required to counteract such effects, aggravating the deleterious effects of ...
A. Morelli +12 more
semanticscholar +1 more source
Objectives: Propofol-based sedation may increase hemodynamic instability by decreasing vascular tone and venous return. Incremental exogenous catecholamines doses may be required to counteract such effects, aggravating the deleterious effects of ...
A. Morelli +12 more
semanticscholar +1 more source
Journal of Clinical Anesthesia, 1989
A review of the pharmacology of propofol, a new IV anesthetic agent, is presented. Solubilized in a soybean emulsion, propofol is one of a series of sterically hindered phenols that exhibit anesthetic activity. Induction of anesthesia with propofol may be associated with pain on injection, apnea, and a reduction in arterial blood pressure (BP) and ...
Mark A. Skues, Cedric Prys-Roberts
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A review of the pharmacology of propofol, a new IV anesthetic agent, is presented. Solubilized in a soybean emulsion, propofol is one of a series of sterically hindered phenols that exhibit anesthetic activity. Induction of anesthesia with propofol may be associated with pain on injection, apnea, and a reduction in arterial blood pressure (BP) and ...
Mark A. Skues, Cedric Prys-Roberts
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Comparison of Propofol‐Lipuro with propofol mixed with lidocaine 10 mg on propofol injection pain
Anaesthesia, 2004SummaryA common drawback of propofol is pain on injection and lidocaine is commonly mixed with propofol to reduce its incidence and severity. We conducted a randomised, prospective, double‐blind study to compare injection pain following the administration of two different formulations of propofol in 200 unpremedicated ASA I–III adult patients scheduled
A. McCluskey, M. S. Abdul-Latif, E. Kam
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Propofol Is a Peroxynitrite Scavenger
Anesthesia & Analgesia, 1997P eroxynitrite is a potent oxidant formed by the rapid reaction between nitric oxide and superoxide radical (1). The peroxynitrite anion is relatively stable, but it can rapidly protonate to peroxynitrous acid, an unstable species, which decomposes with a half-life of about one second at pH 7.4 (1,2).
Demiryurek, AT, Kahraman, S
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Der Anaesthesist, 2004
Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J. Roggenbach, Johann Motsch
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Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h. It has been assumed that the pathophysiologic cause is propofol's impairment of oxidation of fatty acid chains and inhibition of oxidative phosphorylation in the mitochondria, leading to lactate
J. Roggenbach, Johann Motsch
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Techniques in Gastrointestinal Endoscopy, 2009
Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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Endoscopist-directed propofol (EDP) refers to delivery of propofol for endoscopic sedation under the direction of an endoscopist without any involvement of an anesthesia specialist (anesthesiologist or nurse anesthetist). EDP has been proven to be safe and is also cost-effective compared with the anesthetist delivered sedation for endoscopy.
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