Results 91 to 100 of about 8,140,383 (322)

Estimating the proportion of differentially expressed genes in comparative DNA microarray experiments

open access: yes, 2007
DNA microarray experiments, a well-established experimental technique, aim at understanding the function of genes in some biological processes. One of the most common experiments in functional genomics research is to compare two groups of microarray data
Cabrera, Javier, Yu, Ching-Ray
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Democratic Confidence Intervals for comparing two Proportions [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2013
We offer methods to create an accurate graph for comparing confidence intervals for two proportions. The firstmethod involves using weighted sum contrasts when fitting logistic regression with a binary explanatory variable.
Phattrawan Tongkumchum   +3 more
doaj  

A spatial signature of sprawl: or the proportion and distribution of linear networkcircuits [PDF]

open access: yes, 2005
This paper sets out to investigate whether the frequency distribution ofthe linear network circuits within a graph-based representation of aroad transportation system can be helpful in identifying sprawl and, inparticular, whether a 'spatial signature of
Dalton, Nick, Dalton, Ruth
core  

Consistent estimation of the proportion of false nulls and FDR for adaptive multiple testing Normal means under weak dependence

open access: yes, 2022
We consider multiple testing means of many dependent Normal random variables that do not necessarily follow a joint Normal distribution. Under weak dependence, we show the uniform consistency of proportion estimators that are constructed as solutions to ...
Chen, Xiongzhi
core  

Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance Bystander selection, defined as the inadvertent pressure imposed by antibiotic treatment on microbes other than the targeted pathogen, is hypothesized to be a major factor in the propagation of antibiotic resistance, but its extent has not ...
C. Tedijanto   +3 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Non-vanishing of the symmetric square $L$-function at the central point

open access: yes, 2008
Using the mollifier method, we show that for a positive proportion of holomorphic Hecke eigenforms of level one and weight bounded by a large enough constant, the associated symmetric square $L$-function does not vanish at the central point of its ...
Khan, Rizwanur
core   +2 more sources

Trends in Proportion of Women as Authors of Medical Journal Articles, 2008-2018.

open access: yesJAMA Internal Medicine, 2019
Methods | For 9 medical specialties (pediatrics, radiology, anesthesiology, obstetrics and gynecology, neurology, general medicine, dermatology, psychiatry, and oncology), we identified original research articles published between January 1, 2008, and ...
Kamber L. Hart, R. Perlis
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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