Results 121 to 130 of about 3,062,981 (267)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

New to cohort, not new to care: leveraging historical data in HIV clinical cohorts in the United States. [PDF]

Am J Epidemiol
Haw NJL, Hogan B, Humes E, Coburn SB, Zheng C, Cheng Y, Zhang Y, Gebo KA, Lam JO, Karris MY, Zalla LC, Horberg MA, Napravnik S, Gill MJ, Althoff KN, Lesko CR.   +15 more
europepmc   +1 more source

Proportional to the investment [PDF]

British Dental Journal, 2011
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Trends in the Prevalence of Seat Belts Non-use among Adolescents, 2016-2025. [PDF]

Public Health Wkly Rep
Kim Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Variation in emergency department attendances and acute hospital admissions for ambulatory emergency care: a retrospective analysis of routinely collected NHS data across England. [PDF]

BMJ Open
Jacques RM, Simpson RM, Hasan M, Campbell R, Croft S, Croft S, Williams S, Gallier S, Evison F, Dillon A, Glampson B, Davies Q, Knight J, Davis C, George M, Gutteridge C, Sapey E, Denholm R, Mayer E, Chandrabalan V, Stammers M, Mason S, HDRUK UK Regional Linked Data Consortium.   +22 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Trauma patients ≥ 65 years old constitute 40% of severely injured adult trauma patients in Sweden - a 10-year analysis of geriatric trauma prevalence. [PDF]

Eur J Trauma Emerg Surg
Bredberg S, Modalen E, Jöneby C, Nilsson D, Lapidus O.   +4 more
europepmc   +1 more source

In proportion

FORMakademisk, 2020
Avoiding the worst impacts of global warming is a matter of systemic change and political will. An easily adaptable political system would be resilient to the effects of climate change, since a government could maintain effective control by implementing incremental changes.
openaire   +1 more source