Results 121 to 130 of about 6,991,762 (299)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Ecology and EvolutionTrace elements are the essential mineral nutrients in grassland, however, we still know little about the distributions of trace elements in grassland with long‐term grazing exclusion.
Juan Hu, Daowei Zhou
doaj +1 more source
A study of effective factors on being a lean organization (Case study) [PDF]
مدیریت بهره وری, 2009 Lean production is a system that challenges mass production system, and in a short time it has trailed great benefits. This study by examining this production system in one of the big production company in the country i.e.soufian cement co.
Yaguoob Alavi Matın +2 more
doaj
ECONOMIC DISADVANTAGES OF BLACKS IN HIGH BLACK PROPORTION CITIES [PDF]
This paper proposes wage premiums for jobs in high black proportion cities as a source of the continuing economic disadvantages for poor blacks. The estimated hedonic model of individual wages confirms the presence of such wage premiums which result in ...
Bong Joon Yoon, Cheonsoo Park
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Proportional Fuzzy Set Extensions and Imprecise Proportions
InformaticaThe extensions of ordinary fuzzy sets are problematic because they require decimal numbers for membership, non-membership and indecision degrees of an element from the experts, which cannot be easily determined. This will be more difficult when three or more digits’ membership degrees have to be assigned.
openaire +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source