Results 141 to 150 of about 1,577,460 (391)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Secondary electron background produced by heavy nuclei in a multiwire proportional counter hodoscope [PDF]
The secondary electron background produced by heavy nuclei in a multiwire proportional counter hodoscope is calculated using both a simplified and a more complete Monte Carlo model. These results are compared with experimental data from a small multiwire
Morgan, S. H., Jr. +3 more
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Direct comparison between solid state Silicon+6LiF and 3He gas tube neutron detectors
Results in Physics, 2016 During the last decade the worldwide lack of 3He for neutron detection has triggered research and development on alternative technologies and methods.
A. Pappalardo, C. Vasi, P. Finocchiaro
doaj
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Fabrication and evaluation of large-area ultrasoft X-ray detectors suitable for spacecraft application [PDF]
The modifications to the Houston/MSC design of the gas proportional counter flight electronics system are discussed. The following modifications are described: charge amplifier bandwidth improvements, power converter redesign, serial data output buffer ...
Bowyer, S.
core +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
The analysis of the X-ray event analyzer proportional counter data: A comment [PDF]
The findings, based on a comparison of simultaneous observations of a number of flares obtained with the X-REA and SOLRAD 9 instruments, which reveal the degree of deterioration of the counters with time are ...
Wilson, R. M.
core +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source