Results 171 to 180 of about 1,577,460 (391)

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

open access: yesMolecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides   +13 more
wiley   +1 more source

Develop real-time dosimetry concepts and instrumentation for long term missions [PDF]

open access: yes
The development of a rugged portable instrument to evaluate dose and dose equivalent is described. A tissue-equivalent proportional counter simulating a 2 micrometer spherical tissue volume was operated satisfactorily for over a year.
Braby, L. A.
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Revisiting Assumptions that Underlie Estimates of Proportional Entrainment of Delta Smelt by State and Federal Water Diversions from the Sacramento-San Joaquin Delta

open access: yesSan Francisco Estuary and Watershed Science, 2011
The delta smelt is a small, endemic fish that resides in the upper San Francisco Estuary. They are listed under state and federal Endangered Species Acts. Since 2002, their abundance has been at record low levels.
William J. Miller
doaj  

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

On the Analysis of Chemical Composition of Moon's Surface by Direct Methods [PDF]

open access: yes
Proportional counter for X ray emission detection and chemical analysis of lunar surface ...
Bredov, M. M.   +2 more
core   +1 more source

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