Results 171 to 180 of about 1,627,153 (385)

39Ar/Ar measurements using ultra-low background proportional counters

open access: green, 2015
J. Hall   +8 more
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

BILATERAL INTERRELATIONS OF ENMGAND EEG-CHARACTERISTICS OF PYRAMID INSUFFICIENCY IN PATIENTS WITH THE CONSEQUENCES OF STROKE AND OF BRAIN INJURY

open access: yesActa Biomedica Scientifica, 2012
The aim. of the work was to estimate the degree of intensity of interhemispheric interaction with use of complex neurophysiological (electroneuromyography, electroencephalography) testing of 163 patients of 12—74 years in residual period, of ischemic (n =
A. P. Shein   +2 more
doaj  

Independent measurement of the total active 8B solar neutrino flux using an array of 3He proportional counters at the sudbury neutrino observatory

open access: green, 2023
B. Aharmim   +99 more
openalex   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Revisiting Assumptions that Underlie Estimates of Proportional Entrainment of Delta Smelt by State and Federal Water Diversions from the Sacramento-San Joaquin Delta

open access: yesSan Francisco Estuary and Watershed Science, 2011
The delta smelt is a small, endemic fish that resides in the upper San Francisco Estuary. They are listed under state and federal Endangered Species Acts. Since 2002, their abundance has been at record low levels.
William J. Miller
doaj  

The Rutherford Appleton laboratory's mark I multiwire proportional counter positron camera [PDF]

open access: green, 1984
J.E. Bateman   +4 more
openalex   +1 more source

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