Results 141 to 150 of about 459,261 (336)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A novel 14-gene signature for overall survival in lung adenocarcinoma based on the Bayesian hierarchical Cox proportional hazards model [PDF]

, 2022
Na Sun, Jiadong Chu, Wei Hu, Xuanli Chen, Nengjun Yi, Yueping Shen   +5 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Public Sector Union Growth and Bargaining Laws: A Proportional Hazards Approach with Time-Varying Treatments [PDF]

This study uses a Cox proportional hazards model to estimate ther elationship between state-level collective bargaining policies and union growth in the public sector. The proportional hazards analysisis performed with data on approximately eight hundred
Casey Ichniowski
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The effects of short-term training measures on the individual unemployment duration in West Germany [PDF]

Short-term training measures are the most important intervention of German active labor market policy in terms of persons promoted. However, evidence on the impacts of programs is missing.
Hujer, Reinhard, Thomsen, Stephan L., Zeiss, Christopher   +2 more
core  

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Advanced Survival Analysis of Iranian Lung Cancer Patients: Prospective Cohort Study of Prognostic Factors [PDF]

علوم بهداشتی ایران
Background and purpose: Addressing survival in lung cancer patients is crucial because it directly informs prognosis, guides personalized treatment strategies, and highlights disparities in healthcare access.
Mahmood Moosazadeh, Ali Asghar Nadi Ghara, Mobina Gheibi, Ghasem Janbabaei, Akbar Hedayatizadeh Omran, Reza Alizadeh-Navaei, Ramin Shekarriz, Ehsan Zaboli, Mohammad Eslami Jouybari, Erfan Ghadirzadeh   +9 more
doaj  

The Singularity of the Efficiency Bound of the Mixed Proportional Hazard Model [PDF]

, 2001
Geert Ridder, Tiemen Woutersen
openalex  

Robust inference for an interval-monitored step-stress experiment under proportional hazards [PDF]

N. Balakrishnan, María Jaenada, Leandro Pardo   +2 more
openalex   +1 more source