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A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento   +3 more
wiley   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer   +11 more
wiley   +1 more source

Proportional hazards (Cox) regression

Journal of General Internal Medicine, 1993
PROPORTIONAL HAZARDS ( C o x ) REGRESSION is a powerful analytic tool for testing whe the r several factors (e.g., cigarette smoking, hyper tens ion) are independent ly related to the rate (over t ime) of a specific event (e.g., heart attack yes /no) . It can also be used to control for baseline differences be t ween groups in nonrandomized studies and
M H, Katz, W W, Hauck
openaire   +2 more sources

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