Results 71 to 80 of about 191,557 (214)

Prognostic Analysis of IgA Nephropathy Patients with High Risk of CKD Progression Treated with Glucocorticoid: a Retrospective Study [PDF]

Zhongguo quanke yixue
Background IgA nephropathy (IgAN) is a common primary glomerulonephritis worldwide, and the improvement of glucocorticoid on the renal prognosis of IgAN patients with high risk of CKD progression remains unclear.
GAO Ge, ZHANG Xinyue, FENG Yuhua, DOU Jingyu, WU Xueying, CHENG Genyang
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model.

PLoS ONE
BackgroundIn recent years, remarkable progress has been made in the use of machine learning, especially in analyzing prognosis survival data. Traditional prediction models cannot identify interrelationships between factors, and the predictive accuracy is
Huan Zhang, Shan Zhao, Pengzhong Lv
doaj   +1 more source

Out of order: specification check sequencing in Cox models

Political Science Research and Methods
The Cox duration model serves as the basis for more complex duration models like competing risks, repeated events, and multistate models. These models make a number of assumptions, many of which can be assessed empirically, sometimes for substantive ends.
Benjamin T. Jones, Shawna K. Metzger
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Application of Fractional Polynomial Model for Determining Prognostic Factors Associated with Survival of Patients with Gastric Cancer

مجله اپیدمیولوژی ایران, 2013
Background & Objectives: Cox regression model is one of the statistical methods in survival analysis. The use of smoothing techniques in Cox model makes the more accurate estimates for the parameters.
H Noorkojuri, E Hajizadeh, AR Baghestani, MA Pourhoseingholi   +3 more
doaj  

A transformer model for cause-specific hazard prediction

BMC Bioinformatics
Backgroud Modelling discrete-time cause-specific hazards in the presence of competing events and non-proportional hazards is a challenging task in many domains.
Matthieu Oliver, Nicolas Allou, Marjolaine Devineau, Jèrôme Allyn, Cyril Ferdynus   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Relationship between Change in Physical Activity and Risk of Metabolic Syndrome: A Prospective Cohort Study

Journal of Obesity & Metabolic Syndrome
Background : This study investigates the relationship between changes in physical activity levels and risk of metabolic syndrome. Methods : This study examined 1,686 adults aged 40 to 69 years from a community-based cohort study with complete 1st to 4th ...
Doo Yong Park, On Lee, Yong Ho Lee, Chung Gun Lee, Yeon Soo Kim   +4 more
doaj   +1 more source