Results 151 to 160 of about 106,408 (283)

Unsupervised Wing-Bone Morphogroups in Bats Reveal Phylogenetic and Functional Patterns. [PDF]

Integr Org Biol
Zalapa SS, Vargas-Aldaco JM, Guerrero-Vázquez S, López Chávez FJ, Ruiz-Sanchez E.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Stress gradient influence on fatigue crack growth under multiaxial non-proportional loading

, 2007
Commonly, basic experimental fatigue data are derived from unnotched smooth specimens. When this data is transferred to notched components, size effects have to be considered.
Hertel, Olaf, Vormwald, Michael
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Multiaxial fatigue in drill pipes under non-proportional loading

, 2016
The scope of this research is to estimate the fatigue life of drill pipes subjected to multiaxial state of stress. Several approaches that model and estimate fatigue life under non-proportional multiaxial loading were investigated.
Helmy, Nahla
core  

Durability of Three Monthly Loading Doses with Faricimab in Treatment-Naïve Neovascular Age-Related Macular Degeneration. [PDF]

Ophthalmol Ther
Turan L, Bjerager J, Subhi Y, Klefter ON, Hajari JN, Schneider M.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Review of fatigue crack growth under non-proportional loading

, 2012
Cyclic non-proportional loading is common experimental practise for investigations of large structures like vehicles. Numerical analysis of local nonproportional loading conditions is also a well established field of research and application. However,
Vormwald, Michael, Zerres, Patrick
core  

Immediate Loading on Tapered Versus Straight Multiple Implants: A 3-Year Follow-Up of a Randomized Clinical Trial. [PDF]

Clin Implant Dent Relat Res
Song YW, Park SH, Strauss FJ, Yoo SJ, Park JY, Cha JK, Jung UW.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source