Results 81 to 90 of about 175,885 (246)

Proportionality or majoritarianism? In search of electoral equity

Bajo Palabra, 2016
Finding an electoral system both equitable and efficient represents a desideratum for every electoral democracy. The electoral system is at the cornerstone of democracy and has important consequences upon the constitutional and political system as a ...
Elena Cincea
doaj  

Municipal election systems and their implications for ethical and accountable democratic governance at eThekwini Municipality

Journal of Local Government Research and Innovation
Background: The electoral systems adopted for local government offer the citizens the democratic opportunity to elect their representatives through a proportional representative system and constituency electoral system.
Ndwakhulu S. Tshishonga
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A comparative analysis of electoral systems in Indonesia and the Philippines: Structure, process, and political representation

Jurnal Inovasi Ilmu Sosial dan Politik
This study aims to compare the electoral systems, both executive and legislative, in Indonesia and the Philippines by highlighting the differences in institutional structure, implementation mechanisms, and their impact on political representation (the ...
Chandra Dwi Harto Nugroho
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Game changing electoral reforms and party system change? An analysis of the 2020 national assembly election in South Korea

Heliyon
The article analyses the 2020 National Assembly election in South Korea. It was the first legislative election held after President Park Geun-hye had been successfully impeached, and removed from office, in March 2017.
Carl Joergen Saxer
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The Impact of Electoral Systems on the Position of Political Parties in the Parliament (A Comparative Analytical Study)

Zanco Journal of Humanity Sciences
Electoral systems have a great impact on the position of Kurdistan political parties in the elected councils (the Iraqi Council of Representatives, the Kurdistan Parliament, and the Provincial Councils).
Aram Najmadeen Abdulghafoor
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source