Results 121 to 130 of about 1,130,957 (303)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The paper deals with some new indices for ordinal data that arise from sample surveys. Their aim is to measure the degree of concentration to the “positive” or “negative” answers in a given question. The properties of these indices are examined. Moreover,
Perakis, Michael +3 more
core
Expected proportions of larval stages for each rater based on model, and observed proportions.
, 2015 Proportions of larval stages for each rater, as predicted by the model, and observed values.Expected proportions of larval stages for each rater based on model, and observed proportions.
Richard A. Bilonick (284274) +4 more
core +1 more source
Proportional Fuzzy Set Extensions and Imprecise Proportions
InformaticaThe extensions of ordinary fuzzy sets are problematic because they require decimal numbers for membership, non-membership and indecision degrees of an element from the experts, which cannot be easily determined. This will be more difficult when three or more digits’ membership degrees have to be assigned.
openaire +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Cross-classification Proportions.
, 2016 Cross-classification Proportions.
Mark VanDam (2967981) +1 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
OPTIMAL ADVERTISING WITH TRADED RAW AND FINAL GOODS: THE CASE OF VARIABLE PROPORTIONS TECHNOLOGY
An optimal advertising investment rule is derived for a vertically related, competitive market with traded final and raw goods and processing sector characterized by variable proportions technology and nonconstant returns to scale.
Cranfield, John A.L.
core
Pooled phenotypic proportions.
, 2018 Pooled phenotypic proportions.
Getachew Tadesse (3281049) +3 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source