Results 241 to 250 of about 1,130,957 (303)

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

SiteCELL enables <i>on-site</i> PBMCs purification and cryopreservation for immune single-cell profiling of underrepresented ancestries. [PDF]

iScience
Espinosa-Jaime A, Zambada-Moreno O, Corona-Gómez JA, de Jesús-Ortega M, Hernandez-Coronado M, Santos Dias BD, Diniz LA, Leaden L, Cebinelli GM, Marchese D, Rojas-Hidalgo A, Vicencio E, Pérez-Stuardo D, Urquiza-Zurich S, Fajardo ME, Colombo A, Donoso G, Méndez T, Gallo C, Guerrero-Cázares H, Robles-Espinoza CD, Possik PA, Barreto G, Spangenberg L, Verdugo RA, Maracaja-Coutinho V, Severino P, Moreno-Estrada A, Ortiz-Ramírez C.   +28 more
europepmc   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Association of prediabetes phenotypes with metabolic dysfunction-associated fatty liver disease and liver fibrosis: a population-based study. [PDF]

Ther Adv Endocrinol Metab
He M, Liu Y, Gao T, Gu J, Zhou X, Sun Z, Qiu S.   +6 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Representativeness of the Danish Blood Donor Study relative to the general population: a cross-sectional assessment. [PDF]

Sci Rep
Træholt J, Helenius D, Christoffersen LAN, Quinn LJE, Mikkelsen C, Brøns N, Dowsett J, Kaspersen KA, Mikkelsen S, Hansen T, Markussen B, Bruun MT, Aagaard B, Hansen TF, Rostgaard K, Hjalgrim H, Schork AJ, Werge T, Erikstrup C, Pedersen OBV, Sørensen E, Didriksen M, Dinh KM, Ostrowski SR.   +23 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

DNA methylation-estimated phenotypes, telomere length, aging and risk of intracranial aneurysms: Evidence from genetic studies. [PDF]

IBRO Neurosci Rep
Zhang X, Maimaiti A, Xie M, Turhon M, Yalikun N, Liang W.   +5 more
europepmc   +1 more source

High Rates of Return to Sport After Surgical Stabilization for Anterior Shoulder Instability in Athletes: A Systematic Review and Meta-analysis. [PDF]

Orthop J Sports Med
Baur AJ, Houseman TJ, Mansour EZ, Heller RR, Posner MA.   +4 more
europepmc   +1 more source