Results 201 to 210 of about 104,112 (336)

Modulation of the Neurovascular Unit by the Locus Coeruleus–Norepinephrine System: From Physiological Mechanisms to Therapeutic Applications

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The locus coeruleus (LC)–norepinephrine (NE) system significantly influences the structure and function of the neurovascular unit (NVU). The activation degree and firing patterns of LC–NE neurons, as well as the release amount and action sites of NE, profoundly impact the neurons, glial cells, and cerebrovascular components of the NVU.
Zixin Pan, Zhaoxing Jia, Tianxiang Jiang, Qian Cai, Zhong Di, Lin Gan, Congcong Ma, Xianming Lin   +7 more
wiley   +1 more source

Adrenergic signals influence proteomic responses in breast cancer cells. [PDF]

Front Neurosci
Carrasco M, Bjørnstad OV, Vethe H, Akslen LA.   +3 more
europepmc   +1 more source

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity

Chemistry – A European Journal, Volume 31, Issue 57, October 13, 2025.
In the context of developing therapies for dementias and cognitive decline, potent dual acting molecules targeting the GPCR 5HT6 and the enzyme HDAC6 with favorable BBB penetration profile were designed and synthesised. Abstract Alzheimer's Disease (AD) impacts significantly the quality of life of people aged over 65 years old, while millions more ...
Andreas Gkanas, Maria Koutiva, Theodora Katsila, Vivi Bafiti, Minos‐Timotheos Matsoukas, Vasilios Panagiotopoulos, Andrzej J. Bojarski, Theodoros Gkouvitsas, Georgios Moukas, Gerasimos Rassias   +9 more
wiley   +1 more source

TGF-β1 Promotes Angiogenesis via Endothelial-to-Mesenchymal Transition in Infantile Hemangioma. [PDF]

Arterioscler Thromb Vasc Biol
Gong X, Qiu T, Zhou J, Yang K, Xiang S, Zhang Z, Lan Y, Zhang X, Zhou Z, Yang C, Zhang Y, Chen S, Ji Y.   +12 more
europepmc   +1 more source

Mechanisms of the Action of Propranolol and Phenoxybenzamine on the Coronary Artery Tone, an Experimental Study

, 1969
Hiroyasu Ito
openalex   +2 more sources

Enantiocomplementary Bioreduction of Flexible Ring N‐(3‐Oxobutyl)Heterocycles Providing Enantiopure Chiral Fragments for Drug Discovery

ChemBioChem, Volume 26, Issue 19, October 3, 2025.
Bioreduction of flexible ring N‐(3‐oxobutyl)‐heterocycles mediated by enantiocomplementary recombinant alcohol dehydrogenases [an (S)‐selective one from Rhodococcus aetherivorans (RaADH), and an (R)‐selective one from Lactobacillus kefir (LkADH)], as whole‐cell biocatalysts results in enantiopure (S)‐ and (R)‐alcohols (ee > 99%), which are promising ...
Máté Gergő Honvári, Levente András Mócza, Bence Attila Kucsinka, Pál Csuka, Viktória Bódai, Diana Maria Scrob, László Poppe, Gábor Hornyánszky   +7 more
wiley   +1 more source

Blood pressure lowering for prevention of episodic migraine: results of a pilot randomized, placebo-controlled trial of combination blood pressure lowering medication with propranolol. [PDF]

Front Neurol
Carcel C, Haghdoost F, Davies L, Cordato D, Griffiths L, Balicki G, Li Q, Freed R, Anderson CS, Zagami AS, Delcourt C, Rodgers A.   +11 more
europepmc   +1 more source

A Comparison of the Molecular Pharmacological Properties of Current Short, Long, and Ultra‐Long‐Acting β2‐Agonists Used for Asthma and COPD [PDF]

Pharmacol Res Perspect
ABSTRACT β‐agonists have been used in asthma for 120 years. There are two recent changes: ultra‐long‐acting agonists for COPD and new asthma guidelines recommending formoterol/ICS inhalers phasing out short‐acting salbutamol inhalers. Few studies directly compare the molecular pharmacological properties of short (salbutamol, terbutaline, fenoterol ...
Proudman R, Baker J.
europepmc   +2 more sources

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source