Results 231 to 240 of about 104,112 (336)

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal, Nikunjkumar K. Patel, Hannah M. Jones, Savannah McFeely, Shamia L. Faison, Tim Tippin, Odin Naderer   +6 more
wiley   +1 more source

Propranolol and cardiac surgery

The Journal of Thoracic and Cardiovascular Surgery, 1972
G A Kellner, John F. Viljoen, Fawzy G. Estafanous   +2 more
openaire   +4 more sources

[Corrigendum] Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway. [PDF]

Mol Med Rep
Yao TH, Pataer A, Regmi KP, Gu XW, Li QY, Du JT, Ge SM, Tu JB.   +7 more
europepmc   +1 more source

Editorial: Cerebral cavernous malformations. [PDF]

Front Neurol
Zuurbier SM, Santos AN, Flemming KD, Lanzino G, Dammann P, Heldner MR.   +5 more
europepmc   +1 more source

Serum lipids and anticonvulsants [PDF]

, 1982
Berlit, Peter, Heuck, C. C., Krause, Klaus-Henning, Schellenberg, Bernhard   +3 more
core  

Aerobic Exercise Attenuates Autophagy‐Lysosomal Flux Deficits via β2‐AR‐Mediated ESCRT‐III Subunit CHMP4B in Mice With Human MAPT P301L

Aging Cell, Volume 24, Issue 10, October 2025.
MAPT accumulation inhibited CHMP4B expression and thus disrupted ESCRT‐III‐mediated autophagosome‐lysosome fusion, which induced a vicious cycle between MAPT aggregation and autophagic deficits. Aerobic exercise could effectively block the vicious cycle and reverse autophagic deficits by promoting the β2‐AR‐RXRα‐CHMP4B‐ESCRT‐III pathway, reducing ...
Shu‐Guang Bi, Haitao Yu, Tian‐Long Gao, Jia‐Jun Wu, Yu‐Ming Mao, Juan Gong, Fang‐Zhou Wang, Liu Yang, Jia Chen, Zi‐Chong Lan, Meng‐Ting Shen, Yun‐Juan Nie, Gao‐Shang Chai   +12 more
wiley   +1 more source

Clinical Insights into Risk Factors for Infantile Hemangioma and Propranolol Treatment Outcomes. [PDF]

Diagnostics (Basel)
Roșca I, Miulescu RG, Roman AM, Peta OA, Turenschi A, Miu A, Sosoi A, Constantin AT, Năstase L, Miu S, Dinulescu A, Poenaru E, Șandru F.   +12 more
europepmc   +1 more source

Hallucinations and propranolol. [PDF]

BMJ, 1969
openaire   +3 more sources

Antihypertensive therapy for pregnancy hypertension and implications for fetal and neonatal heart rate monitoring: A systematic review of randomized trials and observational studies

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 10, Page 1822-1837, October 2025.
Trials are mostly reassuring regarding antihypertensive effects on fetal (FHR) or neonatal heart rate (neoHR), but observational studies raise concerns about beta‐blockers, particularly the alpha/beta‐blocker labetalol. Clinicians should ascribe adverse fetal or neonatal heart rate effects to evolving underlying placental dysfunction or newborn illness,
Akalya Ganeshamoorthy, Omiete Fubara Duke, Hiten D. Mistry, Jeffrey N. Bone, Marianne Vidler, Edgardo Abalos, Katie Badawy, Asma Khalil, Peter von Dadelszen, Laura A. Magee   +9 more
wiley   +1 more source

Oral preventive medications for migraine in adults aged 18-65: a network meta-analysis. [PDF]

Front Pharmacol
Wu J, Wu J, Zhang J, Liu B, Song X, Wu Y, Tian F, Ding Y, Wang P.   +8 more
europepmc   +1 more source