The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie +20 more
wiley +1 more source
Hypergolic Copper Cluster‐Based Covalent Organic Frameworks
Hpergolic cluster‐based covalent organic framework (Cu3‐CB‐COF), assembled from aldehyde‐functionalized carborane monomers and trinuclear copper clusters, demonstrates a strong synergy between its catalytic copper nodes and energetic carborane backbones.
Yu‐Zhou Qiao +5 more
wiley +1 more source
The Concept of Shaping Applied to Locomotor Interventions: Clinical and Robotic Strategies to Facilitate and Progress Variable Stepping Training at Higher Intensities. [PDF]
Westlake KP +4 more
europepmc +1 more source
Rational engineering of terminal substituents in symmetric azobenzene‐based molecules enables precise control over conformationally coupled charge‐transfer processes. This design yields tunable nonvolatile resistive memory behaviors, ranging from write‐once‐read‐many‐times (WORM) to rewritable switching.
Yanze Liu +11 more
wiley +1 more source
Assessing Neuromuscular Adaptation and Kinetic Symmetry in Elite Para-Kayakers: A Wearable Body Sensor Network Case Series. [PDF]
Saggio G, Pierucci L, Pietrosanti L.
europepmc +1 more source
ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng +19 more
wiley +1 more source
Vertical Jump and Isometric Strength in Professional Female Basketball Players: Starter vs. Non-Starter Comparison. [PDF]
Nieto-Acevedo R +5 more
europepmc +1 more source
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang +11 more
wiley +1 more source
An Exploratory Analysis of Countermovement Jump Variables Between Higher and Lower Performers on the LESS and Y-Balance Tests. [PDF]
Pavlenco C, Talpey S, Gardner EC.
europepmc +1 more source
A regenerative molecular sensing platform that co‐localizes surface‐enhanced Raman spectroscopy (SERS) sensing and nanocavitation‐based actuation. Femtosecond‐laser triggered nanocavitation produces thermomechanical forces to locally regenerate SERS‐active nanogaps in protein‐rich biofluids while preserving optical performance.
Aditya Garg +8 more
wiley +1 more source

