Results 111 to 120 of about 1,685,573 (358)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Anthracycline-induced cardiotoxicity: prospective cohort study from Pakistan [PDF]

, 2013
Objectives: To identify anthracycline-induced acute (within 1 month) and early-onset chronic progressive (within 1 year) cardiotoxicity in children younger than 16 years of age with childhood malignancies at a tertiary care centre of Pakistan.
Ahmed, Mehnaz Atiq, Alam, Muhammad Matloob, Mohsin, Shazia Samad, Saleem, Ali Faisal, Shaikh, Abdul Sattar   +4 more
core   +3 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Higher fracture prevalence and smaller bone size in patients with hEDS/HSD-a prospective cohort study

, 2020
Increased fracture risk in patients with Ehlers-Danlos syndromes has been reported, but the reasons for it are incompletely understood. We aimed to investigate possible determinants of this increased risk and found that hEDS/HSD patients present with a ...
Banica, Thiberiu, Calders, Patrick, Coussens, Marie, De Wandele, Inge, Goemaere, Stefan, Lapauw, Bruno, Malfait, Fransiska, Rombaut, Lies, Verroken, Charlotte, Zmierczak, Hans-Georg   +9 more
core   +1 more source

a prospective ‘before/after’ cohort study [PDF]

, 2015
Objectives Antibiotic resistance has risen dramatically over the past years. For individual patients, adequate initial antibiotic therapy is essential for clinical outcome.
Deja, M., Grebe, M. C., Halle, E., Meyer, E., Musial-Bright, L., Nachtigall, I., Rothbart, A., Spies, C., Tafelski, S., Tamarkin, A., Uhrig, A., Wernecke, K. D.   +11 more
core   +1 more source

Baseline data of a prospective cohort study: Cappadocia cohort study, Turkey

Türkiye Halk Sağlığı Dergisi, 2018
Amac: Bu calismada, Turkiye'nin Kapadokya bolgesinde baslatilan genis bir prospektif kohort calismasinin temel verilerinden kronik hastaliklarin ve davranissal risk faktorlerinin prevalansini belirlemek amaclanmistir. Yontem: Calisma populasyonu Kapadokya bolgesinin iki ilcesi Gulsehir ve Avanos'ta ikamet eden yetiskin gonullulerden olusuyordu.
Serhat Unal, Sibel Ascioglu, Ahmet Demirkazik, Ihsan Ertenli, Erdal Eskioglu, Kerim Guler, Sedat Kiraz, Mert Ozbakkaloglu, Birol Ozer, Tufan Tukek, Mine Durusu Tanriover, Eda Akyar, Pelin Cagatay, Yunus Erdem   +13 more
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Employment status and health after privatisation in white collar civil servants: prospective cohort study [PDF]

, 2001
Objectives To determine whether employment status after job loss due to privatisation influences health and use of health services and whether financial strain, psychosocial measures, or health related behaviours can explain any findings.Design Data ...
Ferrie, JE, Marmot, MG, Martikainen, P, Shipley, MJ, Smith, GD, Stansfeld, SA   +5 more
core  

Research methodology topics: Cohort studies or prospective and retrospective cohort studies

Journal of Human Growth and Development, 2019
In health sciences, the epidemiological method can be divided into descriptive and analytical epidemiology and the latter being divided into observational (cross-sectional study, case-control study and cohort study) and experimental studies. Cohort studies may be retrospective or prospective, and both assume that the researcher will follow a population
Luís Marcelo Aranha Camargo, Romeu Paulo Martins Silva, Dionatas Ulises de Oliveira Meneguetti   +2 more
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source