Results 241 to 250 of about 2,891,973 (365)

Impact of Vitamin D status on age at menopause: A prospective cohort study. [PDF]

J Adv Pharm Technol Res
Muho KH.
europepmc   +1 more source

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

Development of a multidimensional machine learning framework for predicting post-stroke cognitive impairment: A prospective cohort study. [PDF]

Clin Transl Med
He A, Lai H, Yao X, Zhao B, Yan W, Sun W, Wu X, Ma K, Wang Y, Song H.   +9 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Persistent Symptoms in SARS-CoV-2-Infected and Non-Infected Household Members: A Prospective Cohort Study. [PDF]

J Med Virol
Winkel AMAM, de Jonghe BA, Lap CR, Haverkort ME, Sluiter-Post JGC, Euser SM, Eggink D, Geerlings SE, Tami A, de Jong MD, van Lelyveld SFL, van Houten MA.   +11 more
europepmc   +1 more source

Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study

The Lancet, 2019
F. Carrat, H. Fontaine, C. Dorival, Mélanie Simony, A. Diallo, C. Hézode, V. Ledinghen, D. Larrey, G. Haour, J. Bronowicki, F. Zoulim, T. Asselah, P. Marcellin, D. Thabut, V. Leroy, A. Tran, F. Habersetzer, D. Samuel, D. Guyader, O. Chazouilleres, P. Mathurin, S. Metivier, L. Alric, G. Riachi, J. Gournay, A. Abergel, P. Calès, N. Ganne, V. Loustaud-Ratti, L. D’alteroche, X. Causse, Claire Geist, A. Minello, I. Rosa, M. Gelu-Simeon, I. Portal, F. Raffi, M. Bourlière, S. Pol   +38 more
semanticscholar   +1 more source

Tumor‐Informed ctDNA in Guiding First‐Line Immunochemotherapy in Advanced Non‐Small Cell Lung Cancers

Advanced Science, EarlyView.
Tumor‐informed circulating tumor DNA (ctDNA) analysis identifies patients with advanced non‐small cell lung cancer (NSCLC) who benefit from first‐line immunotherapy plus chemotherapy. Longitudinal ctDNA monitoring further reflects therapeutic response and predicts prognosis beyond imaging.
Kailun Fei, Jie Zhao, Jiachen Xu, Jianchun Duan, Chengcheng Li, Wenchuan Xie, Jia Zhong, Guoqiang Wang, Yu Xu, Boyang Sun, Rui Wan, Hua Bai, Qinxiang Guo, Wei Guo, Shangli Cai, Zhijie Wang, Jie Wang   +16 more
wiley   +1 more source

Risk Factors for Suboptimal Dialysis Initiation: A Prospective Cohort Study. [PDF]

Kidney360
Molnar AO, Brimble KS, Bota SE, Kang Y, Harmon JP, Hiremath S, Brown PA, Silver SA, Akbari A.   +8 more
europepmc   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source