Results 151 to 160 of about 39,198 (257)

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Quality of mental health care among insured patients in an Indonesian psychiatric hospital. [PDF]

BMC Health Serv Res
Rachmawaty R, Sri Hariyati RT, Niswar M, Wahyudin E, Bukhari A, Mardatillah R, Kim H.   +6 more
europepmc   +1 more source

Repurposing Registries: Completeness of Real‐World Data for Regulatory and HTA Purposes in Three Cancer‐Focused Registries

Clinical Pharmacology &Therapeutics, EarlyView.
Despite developments in supporting the identification and selection of fit‐for‐purpose registries, a translational gap remains between the original purposes of clinically focused registries and their current and future expected use in policymaking. This study aimed to assess the extent to which cancer‐focused registries collect essential data elements ...
Manon C. Wilpshaar, Doranne Hilarius, Luisa Prada, Ansgar Weltermann, Christine Leopold   +4 more
wiley   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

DRG-based payment and governance in high-complexity thoracic surgery: implications for efficiency and care delivery. [PDF]

Front Health Serv
Ma L, Ma J, Yan X, Chi Y, Wei J, Zhou S, Zhou X, Hu Y, Nie X, Pan J.   +9 more
europepmc   +1 more source

The Relationship Between Board Diversity and Corporate Environmental Performance: A Meta‐Analysis

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The association between corporate governance mechanisms and corporate environmental performance has gained increasing academic engagement; however, existing empirical studies provide inconsistent results. This study aims at empirically summarizing the results of previous research on the relationship between different characteristics of board ...
My Hanh Doan, Paul Ludwig, Remmer Sassen, Luisa Altenburger   +3 more
wiley   +1 more source

Choices and options in the care procurement process of bundled payment contracts: A literature-based overview from a payer's perspective. [PDF]

PLoS One
Steenhuis S, van der Wolk J, van der Hijden E.   +2 more
europepmc   +1 more source

From Nonfinancial Reporting to Management Control: A GRI‐Based Sustainability Balanced Scorecard

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The integration of sustainability into strategic management systems has shifted from a reporting‐oriented exercise to a challenge of implementation, control, and accountability. Although the SBSC is widely acknowledged as a suitable framework to embed environmental and social objectives into strategy execution, its practical application ...
Piedad Ortiz‐Fernández, Belén Payán‐Sánchez, Eva Carmona‐Moreno   +2 more
wiley   +1 more source

The Impact of DRG Review Teams on Obstetric Disease Management and Cost Control: A Variance Analysis Approach. [PDF]

J Obstet Gynaecol Res
Liang X, Zhang R, Liao C, Zhou Y.
europepmc   +1 more source