Results 51 to 60 of about 38,823 (256)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Determinants of Market Share of For-Profit Hospitals: An Empirical Examination

Social Sciences, 2017
This study estimates the effects of a prospective payment system on the growth of for-profit hospitals. The empirical results show that the proportion of patient care paid for by Medicare managed care has a positive, statistically significant ...
Seungchul Lee, Chune Young Chung, Hong Kee Sul, Yunjae Lee   +3 more
doaj   +1 more source

Medicare ESRD Prospective Payment System [PDF]

Journal of the American Society of Nephrology, 2005
On October 30, 1972, President Richard Nixon signed section 2991 of Public Law 92–603, or the 1972 amendments to the Social Security Act. Enacted in July 1973, provisions within this amendment established end-stage renal disease (ESRD) as the only healthcare condition to be covered under ...
Jonathan Himmelfarb, Glenn M. Chertow
openaire   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Is Healthy Competition Healthy? New Evidence of the Impact of Hospital Competition

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2002
Competition among hospitals is commonly regarded as inefficient due to the medical arms race phenomenon, but most evidence for this hypothesis predates the Medicare prospective payment system and preferred provider legislation.
Thomas L. Gift, Richard Arnould, Larry DeBrock   +2 more
doaj   +1 more source

Do Tax Incentives for Farmland Leases Increase Farm Supply? Evidence From Iowa's Beginning Farmer Tax Credit

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT In recent decades, agriculture has become increasingly concentrated through horizontal mergers and acquisitions via corporate entities, and policy makers are concerned this will be exacerbated by the aging population of farm operators. To reduce market concentration in agriculture, many states have enacted policies to entice new prospective ...
Justin M. Ross, Wesley M. Zebrowski, Julia C. D. Valliant   +2 more
wiley   +1 more source

Assessing the Economic Implications of a Diagnosis-Related Groups Payment System in Iran’s Health System Transformation Plan

International Journal of Preventive Medicine
Background: The Health System Transformation Plan (HSTP) in Iran aimed to enhance universal health coverage through improved access and reduced out-of-pocket payments. However, rising healthcare expenditures have posed challenges.
Yousef Khadivi, Mohsen Nabi Meibodi, Fatemeh Saghafi, Reza Khadivi   +3 more
doaj   +1 more source

Why Didn't I Get a Payout? Understanding Farmer Choices, Index Insurance, and Basis Risk

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Index insurance, while heralded as a potential solution to alleviate poverty and food insecurity among agricultural households, has its own set of challenges, notably basis risk. Basis risk is the discrepancy between the insurance payout and losses incurred, posing a significant deterrent to the adoption of index insurance.
S. Lucille Blakeley, Sean Posey, Kathy Baylis, Daniel Osgood, Stuart Sweeney   +4 more
wiley   +1 more source