Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Effect of Hunger on Weight Status and Weight Change: Multiple Cross-Sectional and Prospective Studies. [PDF]
Hernandez L, Marques-Vidal P.
europepmc +1 more source
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Infection risk of peripheral intravenous catheters: meta-synthesis of 18 prospective studies with 14,606 catheters. [PDF]
Rickard CM +12 more
europepmc +1 more source
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu +5 more
wiley +1 more source
Effectiveness and safety of magnetic resonance-guided unilateral focused ultrasound subthalamotomy for Parkinson's disease: a systematic review and meta-analysis of prospective studies. [PDF]
Cheng B +5 more
europepmc +1 more source
Safety of sofosbuvir‐based regimens after liver transplantation: longitudinal assessment of renal function in the prospective
Rodolphe Anty +38 more
openalex +1 more source
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
Sophisticated prospective studies are needed to evaluate the relationship between chronic neck pain and autonomic function. [PDF]
Scorza FA, Scorza CA, Finsterer J.
europepmc +1 more source

