Results 91 to 100 of about 732,067 (314)
On the prospects of longtermism
BioethicsAbstractThis article objects to two arguments that William MacAskill gives in What We Owe the Future in support of optimism about the prospects of longtermism, that is, the prospects of positively influencing the longterm future. First, it grants that he is right that, whereas humans sometimes benefit others as an end, they rarely harm them as an end ...
Persson, I, Savulescu, J
openaire +4 more sources
Central Asia : Mapping Future Prospects [PDF]
Central Asia has emerged as one of the worlds fastest growing regions since the late 1990s and has shown notable development potential. This is significant for a region comprising largely of small landlocked economies with no access to the sea for trade.
Ganeshan Wignaraja, Malcolm Dowling
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PRIVATE EQUITY AS FINANCING SOURCE FOR SMES – AN OUTLOOK [PDF]
Annals of the University of Craiova: Economic Sciences Series, 2019 Nowdays, one of the main barriers against the growth of Small and Medium Enterprises (SMEs) are related to difficulties in accessing finance. These obstacles have multiple causes, such as cyclical, structural but should be also considered the ...
Laura Vasilescu
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
ASEAN Monetary Cooperation : Issues and Prospects [PDF]
Among other things, the 199798 East Asian financial crisis has led to questioning within the Association of Southeast Asian Nations (ASEAN) about whether the region needs a common currency.
Arief Ramayandi
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South Asian Integration Prospects and Lessons from East Asia [PDF]
In the context of the low levels of regional cooperation among South Asian countries when compared with the successful results from cooperation in East Asia (consisting of South East and East Asian countries), the objective of this paper is first to ...
Rajiv Kumar, Ramesh Chandra
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Арктика и СеверFor the sustainable development of territories, it is important to pay special attention to transport infrastructure, which directly affects the level of efficiency and competitiveness of the state (region) economy and forms the creation of a rational ...
Marina N. Kuznetsova +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Implications of the Oil Prospects for Latin America
, 2018 The mix of good short-term prospects for oil revenues along with long-term market uncertainties has a clear policy implication for oil-dependent Latin American economies: use the larger short-term revenues to diversify their economies, nonresident fellow
Ocampo, José Antonio
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