Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Terug aan het werk na een ongeval; wie kan wat van wie vergen? [PDF]
The Prospects of European Private Law (t/m 2009) +2 more
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Preparation and Evaluation of the Remineralization Effect of a Dental Varnish Containing Casein Phosphopeptide-Amorphous Calcium Phosphate with Fluoride (Cpp-Acpf) on White Spot Lesions of Permanent Teeth: An In Vitro Study. [PDF]
Uriat S +3 more
europepmc +1 more source
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Parent-child relationships in Dutch family law [PDF]
Schwenzer, I. +3 more
core +1 more source
Current situation, challenges, and future prospects of the dental radiology education for the medical radiation students in Taiwan. [PDF]
Cheng FC, Ting CY, Chiang CP.
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
An integrated framework for evaluating sustainable outcomes of vocational college graduates under ethnic heterogeneity and unequal college level resource allocation. [PDF]
Zhou J.
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
De aansprakelijkheid van bestuurders en toezichthouders voor schade bij de cliënt, Grondrechten in de gezondheidszorg [PDF]
Sijmons, J.G. +2 more
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