Results 61 to 70 of about 581,425 (317)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Global Economic Prospects 2007 : Managing the Next Wave of Globalization

open access: yes, 2007
Global Economic Prospects (GEP) 2007 explores the next wave of globalization. While the medium-term outlook for the world economy remains fairly bright, demographic trends will be a major driver of future
World Bank
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Enhancing prospects [PDF]

open access: yes, 2016
The tertiary education sector has been an area of both concern and focus lately. The implementation of the National Higher Education Mission and a greater awareness of our dismal performance in university world rankings has garnered a lot of attention ...
Nair, Nisha
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Criteria of assessment of short track runners’ prospects as mean of promising sportsmen losses’ prevention at selection stage

open access: yesPedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2015
Purpose: to offer main criteria for assessment of short track runners’ prospects. Material: 8 sportsmen of short track Ukrainian national team participated in the research. Influence of training means’ volume on result, shown on competition distance, was
S.A. Kugayevskiy
doaj   +1 more source

Prospects for domestic heat pumps

open access: yes, 1983
SIGLEAvailable from British Library Lending Division - LD:84/12185(Prospects) / BLDSC - British Library Document Supply CentreGBUnited ...
Institute of Energy, London (United Kingdom)
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Development of Transit Potential of the Northern Sea Route

open access: yesКонтуры глобальных трансформаций: политика, экономика, право, 2019
The sectoral structure of the Northern sea transport corridor is defined, the set of the transport tasks provided to them - the international transit, import and export operations, internal transportations is considered.
M. N. Grigoryev
doaj   +1 more source

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